A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity

A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity

Abstract Background Osteosarcoma (OS) is one of most commonly diagnosed bone cancer. Circular RNAs (circRNAs) are a class of highly stable non-coding RNA, the majority of which have not been characterized functionally. The underlying function and molecular mechanisms of circRNAs in OS have not been...

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Bibliographic Details
Main Authors: Ying Zhang, Zhaoyong Liu, Zhigang Zhong, Yanchen Ji, Huancheng Guo, Weidong Wang, Chuangzhen Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
circKEAP1
Osteosarcoma
Vimentin
ARIH1
Online Access:https://doi.org/10.1186/s13046-024-02971-7

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