Effect quantification and value prediction of factors in noninvasive detection for specific fetal copy number variants by semiconductor sequencing

Effect quantification and value prediction of factors in noninvasive detection for specific fetal copy number variants by semiconductor sequencing

Abstract Background The detection limit of noninvasive prenatal testing (NIPT) by next generation sequencing for any given fetal copy number variants (CNV) can be influenced by several factors. In this study, we quantified the effects and predicted the value of parameters for CNVs detection by NIPT....

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Bibliographic Details
Main Authors: Chunhua Zhang, Bo Liang, Longwei Qiao, Liming Xuan, Hong Li, Quanze He, Xiaojuan Wu, Jiafeng Lu, Bin Yu, Ting Wang
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
fetal copy number variants
microdeletion
next generation sequencing
noninvasive prenatal testing
Online Access:https://doi.org/10.1002/mgg3.718

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