Pediatric Mixed-Phenotype Acute Leukemia: What’s New?
Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective coll...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/18/4658 |
| _version_ | 1797519999346147328 |
|---|---|
| author | Sandeep Batra Anthony John Ross |
| author_facet | Sandeep Batra Anthony John Ross |
| author_sort | Sandeep Batra |
| collection | DOAJ |
| description | Mixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity. |
| first_indexed | 2024-03-10T07:50:39Z |
| format | Article |
| id | doaj.art-c218fe799bd64544a9f2b444b811bb79 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:50:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c218fe799bd64544a9f2b444b811bb792023-11-22T12:18:36ZengMDPI AGCancers2072-66942021-09-011318465810.3390/cancers13184658Pediatric Mixed-Phenotype Acute Leukemia: What’s New?Sandeep Batra0Anthony John Ross1Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USADepartment of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USAMixed-phenotype acute leukemias (MPAL) are rare in children and often lack consensus on optimal management. This review examines the current controversies and emerging paradigms in the management of pediatric MPAL. We examine risk stratification, outcomes of recent retrospective and prospective collaborative trials, and the role of transplantation and precision genomics, and outline emerging targets and concepts in this rare entity.https://www.mdpi.com/2072-6694/13/18/4658mixed-phenotype acute leukemiaMPAL<i>Ph</i>+<i>MLL</i>lineage switchminimal residual disease |
| spellingShingle | Sandeep Batra Anthony John Ross Pediatric Mixed-Phenotype Acute Leukemia: What’s New? Cancers mixed-phenotype acute leukemia MPAL <i>Ph</i>+ <i>MLL</i> lineage switch minimal residual disease |
| title | Pediatric Mixed-Phenotype Acute Leukemia: What’s New? |
| title_full | Pediatric Mixed-Phenotype Acute Leukemia: What’s New? |
| title_fullStr | Pediatric Mixed-Phenotype Acute Leukemia: What’s New? |
| title_full_unstemmed | Pediatric Mixed-Phenotype Acute Leukemia: What’s New? |
| title_short | Pediatric Mixed-Phenotype Acute Leukemia: What’s New? |
| title_sort | pediatric mixed phenotype acute leukemia what s new |
| topic | mixed-phenotype acute leukemia MPAL <i>Ph</i>+ <i>MLL</i> lineage switch minimal residual disease |
| url | https://www.mdpi.com/2072-6694/13/18/4658 |
| work_keys_str_mv | AT sandeepbatra pediatricmixedphenotypeacuteleukemiawhatsnew AT anthonyjohnross pediatricmixedphenotypeacuteleukemiawhatsnew |