Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report
A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which reve...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/3/410 |
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| author | Noriyuki Arakawa Atsushi Irisawa Kazuyuki Ishida Takuya Tsunoda Yoshiko Yamaguchi Akane Yamabe Makoto Eizuka Shunzo Tokioka Hiroto Wakabayashi |
| author_facet | Noriyuki Arakawa Atsushi Irisawa Kazuyuki Ishida Takuya Tsunoda Yoshiko Yamaguchi Akane Yamabe Makoto Eizuka Shunzo Tokioka Hiroto Wakabayashi |
| author_sort | Noriyuki Arakawa |
| collection | DOAJ |
| description | A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which revealed small bleeding ulcers in the ileocecal region, transverse colon, and rectum. These adverse effects were attributed to the everolimus; it was immediately discontinued, and the patient’s clinical symptoms and imaging findings improved. We concurred that the administration of calcium channel blockers resulted in the inhibition of everolimus metabolism and the disease onset. The everolimus was discontinued. There was no subsequent recurrence of hemorrhagic colitis. |
| first_indexed | 2024-03-09T13:23:42Z |
| format | Article |
| id | doaj.art-c219f127633d4f7eaf83f67e5227cbb5 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:23:42Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-c219f127633d4f7eaf83f67e5227cbb52023-11-30T21:26:36ZengMDPI AGMedicina1010-660X1648-91442022-03-0158341010.3390/medicina58030410Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case ReportNoriyuki Arakawa0Atsushi Irisawa1Kazuyuki Ishida2Takuya Tsunoda3Yoshiko Yamaguchi4Akane Yamabe5Makoto Eizuka6Shunzo Tokioka7Hiroto Wakabayashi8Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, JapanDepartment of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Diagnostic Pathology, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, JapanDepartment of Diagnostic Pathology, Takeda General Hospital, Aizuwakamatsu 965-8585, JapanDepartment of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Internal Medicine, Division of Gastroenterology, Iwate Medical University, Morioka 020-0023, JapanDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, JapanDepartment of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, JapanA 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which revealed small bleeding ulcers in the ileocecal region, transverse colon, and rectum. These adverse effects were attributed to the everolimus; it was immediately discontinued, and the patient’s clinical symptoms and imaging findings improved. We concurred that the administration of calcium channel blockers resulted in the inhibition of everolimus metabolism and the disease onset. The everolimus was discontinued. There was no subsequent recurrence of hemorrhagic colitis.https://www.mdpi.com/1648-9144/58/3/410everolimushemorrhagic colitisnonfunctional pancreatic neuroendocrine neoplasms |
| spellingShingle | Noriyuki Arakawa Atsushi Irisawa Kazuyuki Ishida Takuya Tsunoda Yoshiko Yamaguchi Akane Yamabe Makoto Eizuka Shunzo Tokioka Hiroto Wakabayashi Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report Medicina everolimus hemorrhagic colitis nonfunctional pancreatic neuroendocrine neoplasms |
| title | Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report |
| title_full | Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report |
| title_fullStr | Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report |
| title_full_unstemmed | Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report |
| title_short | Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report |
| title_sort | hemorrhagic colitis caused by everolimus in a patient with nonfunctional pancreatic neuroendocrine neoplasms a case report |
| topic | everolimus hemorrhagic colitis nonfunctional pancreatic neuroendocrine neoplasms |
| url | https://www.mdpi.com/1648-9144/58/3/410 |
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