Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom
Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-10-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/5/10/1799 |
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| author | Guilherme Muricy Eládio Flores Sanchez Suzi Ribeiro Eduardo Coriolano de Oliveira Camila Nunes Faioli Thaisa Francielle Souza Domingos Andre Lopes Fuly |
| author_facet | Guilherme Muricy Eládio Flores Sanchez Suzi Ribeiro Eduardo Coriolano de Oliveira Camila Nunes Faioli Thaisa Francielle Souza Domingos Andre Lopes Fuly |
| author_sort | Guilherme Muricy |
| collection | DOAJ |
| description | Snakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties. |
| first_indexed | 2024-04-13T08:05:07Z |
| format | Article |
| id | doaj.art-c219f8403ff744269fe0c0b055b09ad9 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T08:05:07Z |
| publishDate | 2013-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-c219f8403ff744269fe0c0b055b09ad92022-12-22T02:55:11ZengMDPI AGToxins2072-66512013-10-015101799181310.3390/toxins5101799Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta VenomGuilherme MuricyEládio Flores SanchezSuzi RibeiroEduardo Coriolano de OliveiraCamila Nunes FaioliThaisa Francielle Souza DomingosAndre Lopes FulySnakebites are a health problem in many countries due to the high incidence of such accidents. Antivenom treatment has regularly been used for more than a century, however, this does not neutralize tissue damage and may even increase the severity and morbidity of accidents. Thus, it has been relevant to search for new strategies to improve antiserum therapy, and a variety of molecules from natural sources with antiophidian properties have been reported. In this paper, we analyzed the ability of ten extracts from marine sponges (Amphimedon viridis, Aplysina fulva, Chondrosia collectrix, Desmapsamma anchorata, Dysidea etheria, Hymeniacidon heliophila, Mycale angulosa, Petromica citrina, Polymastia janeirensis, and Tedania ignis) to inhibit the effects caused by Bothrops jararaca and Lachesis muta venom. All sponge extracts inhibited proteolysis and hemolysis induced by both snake venoms, except H. heliophila, which failed to inhibit any biological activity. P. citrina inhibited lethality, hemorrhage, plasma clotting, and hemolysis induced by B. jararaca or L. muta. Moreover, other sponges inhibited hemorrhage induced only by B. jararaca. We conclude that Brazilian sponges may be a useful aid in the treatment of snakebites caused by L. muta and B. jararaca and therefore have potential for the discovery of molecules with antiophidian properties.http://www.mdpi.com/2072-6651/5/10/1799Brazilian spongesBothrops jararacaLachesis mutasnake venomneutralization |
| spellingShingle | Guilherme Muricy Eládio Flores Sanchez Suzi Ribeiro Eduardo Coriolano de Oliveira Camila Nunes Faioli Thaisa Francielle Souza Domingos Andre Lopes Fuly Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom Toxins Brazilian sponges Bothrops jararaca Lachesis muta snake venom neutralization |
| title | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
| title_full | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
| title_fullStr | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
| title_full_unstemmed | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
| title_short | Appraisal of Antiophidic Potential of Marine Sponges against Bothrops jararaca and Lachesis muta Venom |
| title_sort | appraisal of antiophidic potential of marine sponges against bothrops jararaca and lachesis muta venom |
| topic | Brazilian sponges Bothrops jararaca Lachesis muta snake venom neutralization |
| url | http://www.mdpi.com/2072-6651/5/10/1799 |
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