Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018
Abstract Background Overweight and obese females demonstrate a significantly increased risk of anovulatory infertility. This study aims to investigate whether depression score could mediate the association between a body shape index (ABSI) and infertility, especially in overweight and obese populati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-023-02622-7 |
| _version_ | 1827633290668933120 |
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| author | Qiangwei Pan Xiaolu Shen Hongfeng Li Bo Zhu Dake Chen Jiajia Pan |
| author_facet | Qiangwei Pan Xiaolu Shen Hongfeng Li Bo Zhu Dake Chen Jiajia Pan |
| author_sort | Qiangwei Pan |
| collection | DOAJ |
| description | Abstract Background Overweight and obese females demonstrate a significantly increased risk of anovulatory infertility. This study aims to investigate whether depression score could mediate the association between a body shape index (ABSI) and infertility, especially in overweight and obese population. Methods We included 5431 adult female Americans from the National Health and Nutrition Examination Survey (NHANES, 2013–2018) database. ABSI manifested the body shape using waist circumference, weight, and height. Infertility or fertility status was defined by interviewing female participants aged ≥ 18 through the reproductive health questionnaires. Depression symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) with total scores between 0 and 27. To investigate the association of infertility with ABSI and other individual components, survey-weighted multivariable logistic regression was performed. Mediation analysis of PHQ-9 score was conducted to disentangle the pathways that link ABSI to infertility among the NHANES participants. Results 596 (10.97%) females were categorized with having infertility among 5431 participants. Participants with infertility showed higher ABSI and PHQ-9 score, appearing greater population proportion with depression symptoms. In the multivariable logistic regression model, ABSI (adjusted odds ratio = 0.14, 95% CI: 0.04 to 0.50) and PHQ-9 (adjusted odds ratio = 1.04, 95% CI: 1.01 to 1.07) were positively associated with infertility. PHQ-9 score was estimated to mediate 0.2% (P = 0.03) of the link between ABSI and infertility in all individuals, but to mediate 13.5% (P < 0.01) of the ABSI-infertility association in overweight and obese adult females. Conclusion The association between ABSI and infertility seems to be mediated by depression symptoms scored by PHQ-9, especially in those adult females with overweigh and obesity. Future studies should be implemented to further explore this mediator in ABSI-infertility link. |
| first_indexed | 2024-03-09T14:57:28Z |
| format | Article |
| id | doaj.art-c21a0de62c1c4ecbb5cc9de72d86cf2b |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-09T14:57:28Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-c21a0de62c1c4ecbb5cc9de72d86cf2b2023-11-26T14:07:21ZengBMCBMC Women's Health1472-68742023-09-012311910.1186/s12905-023-02622-7Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018Qiangwei Pan0Xiaolu Shen1Hongfeng Li2Bo Zhu3Dake Chen4Jiajia Pan5Department of Reproductive Endocrinology, Wenzhou People’s hospitalDepartment of Reproductive Endocrinology, Wenzhou People’s hospitalDepartment of Gynecology, the Affiliated People’s Hospital of Ningbo UniversityDepartment of Reproductive Endocrinology, Wenzhou People’s hospitalDepartment of Urology Surgery, Wenzhou People’s hospitalDepartment of Gynecology, Wenzhou People’s hospitalAbstract Background Overweight and obese females demonstrate a significantly increased risk of anovulatory infertility. This study aims to investigate whether depression score could mediate the association between a body shape index (ABSI) and infertility, especially in overweight and obese population. Methods We included 5431 adult female Americans from the National Health and Nutrition Examination Survey (NHANES, 2013–2018) database. ABSI manifested the body shape using waist circumference, weight, and height. Infertility or fertility status was defined by interviewing female participants aged ≥ 18 through the reproductive health questionnaires. Depression symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) with total scores between 0 and 27. To investigate the association of infertility with ABSI and other individual components, survey-weighted multivariable logistic regression was performed. Mediation analysis of PHQ-9 score was conducted to disentangle the pathways that link ABSI to infertility among the NHANES participants. Results 596 (10.97%) females were categorized with having infertility among 5431 participants. Participants with infertility showed higher ABSI and PHQ-9 score, appearing greater population proportion with depression symptoms. In the multivariable logistic regression model, ABSI (adjusted odds ratio = 0.14, 95% CI: 0.04 to 0.50) and PHQ-9 (adjusted odds ratio = 1.04, 95% CI: 1.01 to 1.07) were positively associated with infertility. PHQ-9 score was estimated to mediate 0.2% (P = 0.03) of the link between ABSI and infertility in all individuals, but to mediate 13.5% (P < 0.01) of the ABSI-infertility association in overweight and obese adult females. Conclusion The association between ABSI and infertility seems to be mediated by depression symptoms scored by PHQ-9, especially in those adult females with overweigh and obesity. Future studies should be implemented to further explore this mediator in ABSI-infertility link.https://doi.org/10.1186/s12905-023-02622-7ABSIInfertilityOverweightObesityDepression scoreNHANES |
| spellingShingle | Qiangwei Pan Xiaolu Shen Hongfeng Li Bo Zhu Dake Chen Jiajia Pan Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 BMC Women's Health ABSI Infertility Overweight Obesity Depression score NHANES |
| title | Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 |
| title_full | Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 |
| title_fullStr | Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 |
| title_full_unstemmed | Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 |
| title_short | Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018 |
| title_sort | depression score mediate the association between a body shape index and infertility in overweight and obesity females nhanes 2013 2018 |
| topic | ABSI Infertility Overweight Obesity Depression score NHANES |
| url | https://doi.org/10.1186/s12905-023-02622-7 |
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