The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome
Abstract Polycystic ovarian syndrome (PCOS) is the most common multifactor heterogeneous endocrine and metabolic disease in women of childbearing age. PCOS is a group of clinical syndromes characterized by reproductive disorders, metabolic disorders, and mental health problems that seriously impact...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00746-4 |
| _version_ | 1811188835438034944 |
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| author | Mali Wu Jie Zhang Ran Gu Fangfang Dai Dongyong Yang Yajing Zheng Wei Tan Yifan Jia Bingshu Li Yanxiang Cheng |
| author_facet | Mali Wu Jie Zhang Ran Gu Fangfang Dai Dongyong Yang Yajing Zheng Wei Tan Yifan Jia Bingshu Li Yanxiang Cheng |
| author_sort | Mali Wu |
| collection | DOAJ |
| description | Abstract Polycystic ovarian syndrome (PCOS) is the most common multifactor heterogeneous endocrine and metabolic disease in women of childbearing age. PCOS is a group of clinical syndromes characterized by reproductive disorders, metabolic disorders, and mental health problems that seriously impact the physical and mental health of patients. At present, new studies suggest that human evolution leads to the body changes and the surrounding environment mismatch adaptation, but the understanding of the disease is still insufficient, the pathogenesis is still unclear. Sirtuin 1 (SIRT1), a member of the Sirtuin family, is expressed in various cells and plays a crucial role in cell energy conversion and physiological metabolism. Pathophysiological processes such as cell proliferation and apoptosis, autophagy, metabolism, inflammation, antioxidant stress and insulin resistance play a crucial role. Moreover, SIRT1 participates in the pathophysiological processes of oxidative stress, autophagy, ovulation disturbance and insulin resistance, which may be a vital link in the occurrence of PCOS. Hence, the study of the role of SIRT1 in the pathogenesis of PCOS and related complications will contribute to a more thorough understanding of the pathogenesis of PCOS and supply a basis for the treatment of patients. |
| first_indexed | 2024-04-11T14:25:56Z |
| format | Article |
| id | doaj.art-c21a494412134c4e98e51104b7ebbec3 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-11T14:25:56Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-c21a494412134c4e98e51104b7ebbec32022-12-22T04:18:53ZengBMCEuropean Journal of Medical Research2047-783X2022-08-0127111010.1186/s40001-022-00746-4The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndromeMali Wu0Jie Zhang1Ran Gu2Fangfang Dai3Dongyong Yang4Yajing Zheng5Wei Tan6Yifan Jia7Bingshu Li8Yanxiang Cheng9Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Pain, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan UniversityAbstract Polycystic ovarian syndrome (PCOS) is the most common multifactor heterogeneous endocrine and metabolic disease in women of childbearing age. PCOS is a group of clinical syndromes characterized by reproductive disorders, metabolic disorders, and mental health problems that seriously impact the physical and mental health of patients. At present, new studies suggest that human evolution leads to the body changes and the surrounding environment mismatch adaptation, but the understanding of the disease is still insufficient, the pathogenesis is still unclear. Sirtuin 1 (SIRT1), a member of the Sirtuin family, is expressed in various cells and plays a crucial role in cell energy conversion and physiological metabolism. Pathophysiological processes such as cell proliferation and apoptosis, autophagy, metabolism, inflammation, antioxidant stress and insulin resistance play a crucial role. Moreover, SIRT1 participates in the pathophysiological processes of oxidative stress, autophagy, ovulation disturbance and insulin resistance, which may be a vital link in the occurrence of PCOS. Hence, the study of the role of SIRT1 in the pathogenesis of PCOS and related complications will contribute to a more thorough understanding of the pathogenesis of PCOS and supply a basis for the treatment of patients.https://doi.org/10.1186/s40001-022-00746-4PCOSSIRT1Oxidative stressAutophagyTreatment |
| spellingShingle | Mali Wu Jie Zhang Ran Gu Fangfang Dai Dongyong Yang Yajing Zheng Wei Tan Yifan Jia Bingshu Li Yanxiang Cheng The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome European Journal of Medical Research PCOS SIRT1 Oxidative stress Autophagy Treatment |
| title | The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| title_full | The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| title_fullStr | The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| title_full_unstemmed | The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| title_short | The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| title_sort | role of sirtuin 1 in the pathophysiology of polycystic ovary syndrome |
| topic | PCOS SIRT1 Oxidative stress Autophagy Treatment |
| url | https://doi.org/10.1186/s40001-022-00746-4 |
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