Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets
Sessile droplets play a crucial role in the microreactors of biochemical samples. Acoustofluidics provide a non-contact and label-free method for manipulating particles, cells, and chemical analytes in droplets. In the present study, we propose a micro-stirring application based on acoustic swirls i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/14/4/837 |
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| author | Huaize Lan Jingui Qian Yansong Liu Shanshan Lu Bowei Zhang Liang Huang Xuefeng Hu Wei Zhang |
| author_facet | Huaize Lan Jingui Qian Yansong Liu Shanshan Lu Bowei Zhang Liang Huang Xuefeng Hu Wei Zhang |
| author_sort | Huaize Lan |
| collection | DOAJ |
| description | Sessile droplets play a crucial role in the microreactors of biochemical samples. Acoustofluidics provide a non-contact and label-free method for manipulating particles, cells, and chemical analytes in droplets. In the present study, we propose a micro-stirring application based on acoustic swirls in sessile droplets. The acoustic swirls are formed inside the droplets by asymmetric coupling of surface acoustic waves (SAWs). With the merits of the slanted design of the interdigital electrode, the excitation position of SAWs is selective by sweeping in wide frequency ranges, allowing for the droplet position to be customized within the aperture region. We verify the reasonable existence of acoustic swirls in sessile droplets by a combination of simulations and experiments. The different periphery of the droplet meeting with SAWs will produce acoustic streaming phenomena with different intensities. The experiments demonstrate that acoustic swirls formed after SAWs encountering droplet boundaries will be more obvious. The acoustic swirls have strong stirring abilities to rapidly dissolve the yeast cell powder granules. Therefore, acoustic swirls are expected to be an effective means for rapid stirring of biomolecules and chemicals, providing a new approach to micro-stirring in biomedicine and chemistry. |
| first_indexed | 2024-03-11T04:43:53Z |
| format | Article |
| id | doaj.art-c21d3fc5f53146a0b5e6cbb9d2d59db9 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-11T04:43:53Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-c21d3fc5f53146a0b5e6cbb9d2d59db92023-11-17T20:30:05ZengMDPI AGMicromachines2072-666X2023-04-0114483710.3390/mi14040837Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile DropletsHuaize Lan0Jingui Qian1Yansong Liu2Shanshan Lu3Bowei Zhang4Liang Huang5Xuefeng Hu6Wei Zhang7Anhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaAnhui Province Key Laboratory of Measuring Theory and Precision Instrument, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, ChinaSessile droplets play a crucial role in the microreactors of biochemical samples. Acoustofluidics provide a non-contact and label-free method for manipulating particles, cells, and chemical analytes in droplets. In the present study, we propose a micro-stirring application based on acoustic swirls in sessile droplets. The acoustic swirls are formed inside the droplets by asymmetric coupling of surface acoustic waves (SAWs). With the merits of the slanted design of the interdigital electrode, the excitation position of SAWs is selective by sweeping in wide frequency ranges, allowing for the droplet position to be customized within the aperture region. We verify the reasonable existence of acoustic swirls in sessile droplets by a combination of simulations and experiments. The different periphery of the droplet meeting with SAWs will produce acoustic streaming phenomena with different intensities. The experiments demonstrate that acoustic swirls formed after SAWs encountering droplet boundaries will be more obvious. The acoustic swirls have strong stirring abilities to rapidly dissolve the yeast cell powder granules. Therefore, acoustic swirls are expected to be an effective means for rapid stirring of biomolecules and chemicals, providing a new approach to micro-stirring in biomedicine and chemistry.https://www.mdpi.com/2072-666X/14/4/837SAWssessile dropletsacoustic swirlsacoustic microdevicesstirring |
| spellingShingle | Huaize Lan Jingui Qian Yansong Liu Shanshan Lu Bowei Zhang Liang Huang Xuefeng Hu Wei Zhang Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets Micromachines SAWs sessile droplets acoustic swirls acoustic microdevices stirring |
| title | Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets |
| title_full | Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets |
| title_fullStr | Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets |
| title_full_unstemmed | Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets |
| title_short | Swirl-like Acoustofluidic Stirring Facilitates Microscale Reactions in Sessile Droplets |
| title_sort | swirl like acoustofluidic stirring facilitates microscale reactions in sessile droplets |
| topic | SAWs sessile droplets acoustic swirls acoustic microdevices stirring |
| url | https://www.mdpi.com/2072-666X/14/4/837 |
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