Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan
The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a significant public health problem and has led to a setback in efforts to end tuberculosis (TB) worldwide. The longer duration, heavier pill load, and higher toxicity profile of DR-TB regimens compared to those for dr...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-08-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://monaldi-archives.org/index.php/macd/article/view/2618 |
| _version_ | 1827874945303052288 |
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| author | Roshni Mary Prince Suman Khangarot Qazi Faizanul Haque Anish Mittal Ramdhan Somani Mansha Grover |
| author_facet | Roshni Mary Prince Suman Khangarot Qazi Faizanul Haque Anish Mittal Ramdhan Somani Mansha Grover |
| author_sort | Roshni Mary Prince |
| collection | DOAJ |
| description |
The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a significant public health problem and has led to a setback in efforts to end tuberculosis (TB) worldwide. The longer duration, heavier pill load, and higher toxicity profile of DR-TB regimens compared to those for drug-susceptible TB (DS-TB) lead to reduced adherence and worse treatment results, including mortality. This study was conducted to estimate treatment outcomes and adverse effects in patients with drug-resistant TB patients on bedaquiline-containing regimen. Patients after the pre-treatment evaluation were enrolled for bedaquiline-containing regimen. These patients were followed up for 18 months and the final outcome was assessed along with the adverse effects. It was found that 49 (84.4%) patients achieved culture conversion by three months and 54 (93.1%) achieved culture conversion by six months, 52 (83.81%) patients had favourable outcomes (cured, treatment completed) and 10 patients had unfavourable outcomes (died, lost to follow-up, failed). Coupled with gradually increasing trends of success rates from 2012, lesser failure rates and lesser concerns regarding grave adverse effects are a silver lining along the cloud of increasing burden and widening resistance patterns. More funding has to be directed towards ensuring adherence and finding high-risk individuals in order to expedite the achievement of sustainable development (SDG) goals.
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| first_indexed | 2024-03-12T16:59:06Z |
| format | Article |
| id | doaj.art-c21d5cfcd7fa46838d9e4d420c864d39 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-03-12T16:59:06Z |
| publishDate | 2023-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-c21d5cfcd7fa46838d9e4d420c864d392023-08-07T18:33:33ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642023-08-0110.4081/monaldi.2023.2618Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of RajasthanRoshni Mary Prince0Suman Khangarot1Qazi Faizanul Haque2Anish Mittal3Ramdhan Somani4Mansha Grover5Department of Respiratory Medicine, Government Medical College, KotaDepartment of Respiratory Medicine, Government Medical College, KotaDepartment of Respiratory Medicine, Government Medical College, KotaDepartment of Respiratory Medicine, Government Medical College, KotaDepartment of Respiratory Medicine, Government Medical College, KotaDepartment of Respiratory Medicine, Government Medical College, Kota The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a significant public health problem and has led to a setback in efforts to end tuberculosis (TB) worldwide. The longer duration, heavier pill load, and higher toxicity profile of DR-TB regimens compared to those for drug-susceptible TB (DS-TB) lead to reduced adherence and worse treatment results, including mortality. This study was conducted to estimate treatment outcomes and adverse effects in patients with drug-resistant TB patients on bedaquiline-containing regimen. Patients after the pre-treatment evaluation were enrolled for bedaquiline-containing regimen. These patients were followed up for 18 months and the final outcome was assessed along with the adverse effects. It was found that 49 (84.4%) patients achieved culture conversion by three months and 54 (93.1%) achieved culture conversion by six months, 52 (83.81%) patients had favourable outcomes (cured, treatment completed) and 10 patients had unfavourable outcomes (died, lost to follow-up, failed). Coupled with gradually increasing trends of success rates from 2012, lesser failure rates and lesser concerns regarding grave adverse effects are a silver lining along the cloud of increasing burden and widening resistance patterns. More funding has to be directed towards ensuring adherence and finding high-risk individuals in order to expedite the achievement of sustainable development (SDG) goals. https://monaldi-archives.org/index.php/macd/article/view/2618tuberculosisMDR tuberculosisXDR-TBdiarylquinoline |
| spellingShingle | Roshni Mary Prince Suman Khangarot Qazi Faizanul Haque Anish Mittal Ramdhan Somani Mansha Grover Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan Monaldi Archives for Chest Disease tuberculosis MDR tuberculosis XDR-TB diarylquinoline |
| title | Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan |
| title_full | Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan |
| title_fullStr | Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan |
| title_full_unstemmed | Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan |
| title_short | Outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of Rajasthan |
| title_sort | outcomes of bedaquiline containing regimen in the treatment of adults with drug resistant tuberculosis in a tertiary care centre of rajasthan |
| topic | tuberculosis MDR tuberculosis XDR-TB diarylquinoline |
| url | https://monaldi-archives.org/index.php/macd/article/view/2618 |
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