cGAS-independent STING activation in response to DNA damage
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1558682 |
| _version_ | 1827809366247473152 |
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| author | Leonie Unterholzner Gillian Dunphy |
| author_facet | Leonie Unterholzner Gillian Dunphy |
| author_sort | Leonie Unterholzner |
| collection | DOAJ |
| description | Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes). |
| first_indexed | 2024-03-11T22:41:09Z |
| format | Article |
| id | doaj.art-c21e36daf78646479a98caf0a5c487d2 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:09Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-c21e36daf78646479a98caf0a5c487d22023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-07-016410.1080/23723556.2018.15586821558682cGAS-independent STING activation in response to DNA damageLeonie Unterholzner0Gillian Dunphy1Lancaster UniversityLancaster UniversitySelf-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).http://dx.doi.org/10.1080/23723556.2018.1558682dna damageinnate immunityetoposidestingifi16 |
| spellingShingle | Leonie Unterholzner Gillian Dunphy cGAS-independent STING activation in response to DNA damage Molecular & Cellular Oncology dna damage innate immunity etoposide sting ifi16 |
| title | cGAS-independent STING activation in response to DNA damage |
| title_full | cGAS-independent STING activation in response to DNA damage |
| title_fullStr | cGAS-independent STING activation in response to DNA damage |
| title_full_unstemmed | cGAS-independent STING activation in response to DNA damage |
| title_short | cGAS-independent STING activation in response to DNA damage |
| title_sort | cgas independent sting activation in response to dna damage |
| topic | dna damage innate immunity etoposide sting ifi16 |
| url | http://dx.doi.org/10.1080/23723556.2018.1558682 |
| work_keys_str_mv | AT leonieunterholzner cgasindependentstingactivationinresponsetodnadamage AT gilliandunphy cgasindependentstingactivationinresponsetodnadamage |