Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation
Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02884-x |
| _version_ | 1818573873886527488 |
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| author | Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang |
| author_facet | Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang |
| author_sort | Shuwei Zhou |
| collection | DOAJ |
| description | Abstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of twin pregnancies with PPROM occurring at 24 0/7 to 33 6/7 weeks’ gestation. Perinatal outcomes were assessed by gestational age (GA) at PPROM and compared between PPROM and non PPROM twins. Factors associated with discharge without severe or moderate-severe neonatal morbidity were identified using logistic regression analysis. Of the 180 pregnancies (360 foetuses), only 17 (9.4%) women remained pregnant 7 days after PPROM. There were 10 (2.8%) cases of prenatal or neonatal death; 303 (84.2%) and 177 (49.2%) neonates were discharged without severe or moderate-severe morbidity, respectively. As GA at PPROM increased, the adverse obstetric and neonatal outcomes decreased, especially after 32 weeks. There was no significant difference in general neonatal outcomes between PPROM and non PPROM twins. The GA at PPROM and latency period were both significantly associated with discharge without severe or moderate-severe neonatal morbidity. Pregnancy complications and 5-min Apgar score < 7 increased severe neonatal morbidity. As GA at PPROM increased, the risk of adverse perinatal outcomes decreased. GA at PPROM and latency period were significantly associated with discharge without severe or moderate-severe neonatal morbidity. |
| first_indexed | 2024-12-15T00:18:43Z |
| format | Article |
| id | doaj.art-c21ea009629d47ecbfe189cd57eabc07 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-15T00:18:43Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c21ea009629d47ecbfe189cd57eabc072022-12-21T22:42:23ZengNature PortfolioScientific Reports2045-23222021-12-0111111010.1038/s41598-021-02884-xPerinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestationShuwei Zhou0Yajun Yang1XiaoYan Zhang2Xiaoling Mu3Quan Quan4Qimei Zhong5Lingwei Mei6Lan Wang7Department of Obstetrics, Chongqing Health Center for Women and ChildrenDepartment of Obstetrics, Chongqing Health Center for Women and ChildrenDepartment of Obstetrics, Chongqing Health Center for Women and ChildrenDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Obstetrics, Chongqing Health Center for Women and ChildrenDepartment of Obstetrics, Chongqing Health Center for Women and ChildrenDepartment of Obstetrics, Chongqing Health Center for Women and ChildrenAbstract To describe the perinatal outcomes of twin pregnancies with preterm premature rupture of membranes (PPROM) before 34 weeks’ gestation and identify factors associated with discharge without severe or moderate-severe neonatal morbidity. This study was conducted as a retrospective analysis of twin pregnancies with PPROM occurring at 24 0/7 to 33 6/7 weeks’ gestation. Perinatal outcomes were assessed by gestational age (GA) at PPROM and compared between PPROM and non PPROM twins. Factors associated with discharge without severe or moderate-severe neonatal morbidity were identified using logistic regression analysis. Of the 180 pregnancies (360 foetuses), only 17 (9.4%) women remained pregnant 7 days after PPROM. There were 10 (2.8%) cases of prenatal or neonatal death; 303 (84.2%) and 177 (49.2%) neonates were discharged without severe or moderate-severe morbidity, respectively. As GA at PPROM increased, the adverse obstetric and neonatal outcomes decreased, especially after 32 weeks. There was no significant difference in general neonatal outcomes between PPROM and non PPROM twins. The GA at PPROM and latency period were both significantly associated with discharge without severe or moderate-severe neonatal morbidity. Pregnancy complications and 5-min Apgar score < 7 increased severe neonatal morbidity. As GA at PPROM increased, the risk of adverse perinatal outcomes decreased. GA at PPROM and latency period were significantly associated with discharge without severe or moderate-severe neonatal morbidity.https://doi.org/10.1038/s41598-021-02884-x |
| spellingShingle | Shuwei Zhou Yajun Yang XiaoYan Zhang Xiaoling Mu Quan Quan Qimei Zhong Lingwei Mei Lan Wang Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation Scientific Reports |
| title | Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation |
| title_full | Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation |
| title_fullStr | Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation |
| title_full_unstemmed | Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation |
| title_short | Perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24–34 weeks’ gestation |
| title_sort | perinatal outcomes of twin pregnancies with preterm premature rupture of the membranes at 24 34 weeks gestation |
| url | https://doi.org/10.1038/s41598-021-02884-x |
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