Evolution of genetically determined generalized epilepsies
This article analyzes the available literature regarding the clinical manifestations, genetic determinants, prognosis and evolution of inherited generalized epilepsies. We describe the typical EEG characteristics and their correlations with negative prognostic factors. We also review studies on abse...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2019-07-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/478 |
| _version_ | 1797879404894879744 |
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| author | E. A. Morozova F. I. Gusyakov |
| author_facet | E. A. Morozova F. I. Gusyakov |
| author_sort | E. A. Morozova |
| collection | DOAJ |
| description | This article analyzes the available literature regarding the clinical manifestations, genetic determinants, prognosis and evolution of inherited generalized epilepsies. We describe the typical EEG characteristics and their correlations with negative prognostic factors. We also review studies on absence epilepsy of childhood, juvenile myoclonic epilepsy and epilepsy with generalized tonic-clonic seizures. Factors indicating a more severe course and outcome of the disease, and those indicating a more favorable development have been analyzed. Among those, age of the seizure onset, type of initial therapy, time passed before starting therapy and time before a response was seen, cognitive status, combination of seizures, abnormal discharges in EEG, and neurological deficit. The analysis shows that factors correlating with poor prognosis include the presence of more than one type of seizures, insufficient response to initial therapy, necessity of polytherapy and concomitant cognitive impairment. |
| first_indexed | 2024-04-10T02:47:06Z |
| format | Article |
| id | doaj.art-c21ec964241449b0ae389cf993bcb521 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:47:06Z |
| publishDate | 2019-07-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-c21ec964241449b0ae389cf993bcb5212023-03-13T07:44:17ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882019-07-0111218719410.17749/2077-8333.2019.11.2.187-194447Evolution of genetically determined generalized epilepsiesE. A. Morozova0F. I. Gusyakov1Kazan State Medical Academy - branch of the Federal state budgetary educational institution of additional professional education “Russian medical Academy of continuous professional education” of the Ministry of health of the Russian FederationChildren’s City Hospital № 8This article analyzes the available literature regarding the clinical manifestations, genetic determinants, prognosis and evolution of inherited generalized epilepsies. We describe the typical EEG characteristics and their correlations with negative prognostic factors. We also review studies on absence epilepsy of childhood, juvenile myoclonic epilepsy and epilepsy with generalized tonic-clonic seizures. Factors indicating a more severe course and outcome of the disease, and those indicating a more favorable development have been analyzed. Among those, age of the seizure onset, type of initial therapy, time passed before starting therapy and time before a response was seen, cognitive status, combination of seizures, abnormal discharges in EEG, and neurological deficit. The analysis shows that factors correlating with poor prognosis include the presence of more than one type of seizures, insufficient response to initial therapy, necessity of polytherapy and concomitant cognitive impairment.https://www.epilepsia.su/jour/article/view/478generalized epilepsyoutcomesevolutionchildhood absence epilepsycaejuvenile myoclonic epilepsyjmeepilepsy with generalized tonic-clonic seizures alone |
| spellingShingle | E. A. Morozova F. I. Gusyakov Evolution of genetically determined generalized epilepsies Эпилепсия и пароксизмальные состояния generalized epilepsy outcomes evolution childhood absence epilepsy cae juvenile myoclonic epilepsy jme epilepsy with generalized tonic-clonic seizures alone |
| title | Evolution of genetically determined generalized epilepsies |
| title_full | Evolution of genetically determined generalized epilepsies |
| title_fullStr | Evolution of genetically determined generalized epilepsies |
| title_full_unstemmed | Evolution of genetically determined generalized epilepsies |
| title_short | Evolution of genetically determined generalized epilepsies |
| title_sort | evolution of genetically determined generalized epilepsies |
| topic | generalized epilepsy outcomes evolution childhood absence epilepsy cae juvenile myoclonic epilepsy jme epilepsy with generalized tonic-clonic seizures alone |
| url | https://www.epilepsia.su/jour/article/view/478 |
| work_keys_str_mv | AT eamorozova evolutionofgeneticallydeterminedgeneralizedepilepsies AT figusyakov evolutionofgeneticallydeterminedgeneralizedepilepsies |