Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields
<p>Abstract</p> <p>The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, w...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2009-01-01
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| Series: | Nanoscale Research Letters |
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| Online Access: | http://dx.doi.org/10.1007/s11671-009-9332-8 |
| Summary: | <p>Abstract</p> <p>The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.</p> |
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| ISSN: | 1931-7573 1556-276X |