Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
Purpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing ho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/5/1281 |
| _version_ | 1797569366859972608 |
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| author | Se Young Choi Byung Hoon Chi Wonchul Lee Bumjin Lim Dalsan You Choung-Soo Kim |
| author_facet | Se Young Choi Byung Hoon Chi Wonchul Lee Bumjin Lim Dalsan You Choung-Soo Kim |
| author_sort | Se Young Choi |
| collection | DOAJ |
| description | Purpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), were measured in 415 patients diagnosed with prostate cancer. Differences in serum hormone concentrations after receiving androgen deprivation therapy (ADT) and after withdrawal from ADT were evaluated. Pathologic characteristics were assessed in the 225 patients unexposed to ADT with a history of radical prostatectomy. Logistic regression analysis was performed to identify factors predictive of unfavorable pathology (Grade ≥3, ≥T3a, or N1). Results: Of the 415 prostate cancer patients, 130 (31.3%) were assessed before treatment, 171 (41.2%) after surgery, 35 (8.4%) after biochemical recurrence, and 59 (14.2%) during ADT, whereas 20 (4.8%) had castration-resistant prostate cancer. FSH was significantly lower after compared to before prostatectomy (3.229 ± 4.486 vs. 5.941 ± 7.044 mIU/mL, <i>p</i> < 0.001). LH, FSH, and testosterone decreased significantly 3 months after starting ADT, but increased 3 months after ADT withdrawal, whereas SHBG was unchanged. Multivariate analysis showed that high LH (odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.03–2.47, <i>p</i> = 0.0376) and prostate-specific antigen (PSA) (OR: 1.13, 95% CI: 1.03–1.24, <i>p</i> = 0.0133) concentrations were significantly associated with a high risk of unfavorable pathology. Conclusions: Sex hormones, including LH, FSH, and testosterone, were affected by ADT. The FSH level decreased after radical prostatectomy. High baseline LH concentration in patients unexposed to ADT was associated with an unfavorable pathology. |
| first_indexed | 2024-03-10T20:09:49Z |
| format | Article |
| id | doaj.art-c222b672baa7449db732be0540eeea2e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T20:09:49Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c222b672baa7449db732be0540eeea2e2023-11-19T22:59:58ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0195128110.3390/jcm9051281Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate CancerSe Young Choi0Byung Hoon Chi1Wonchul Lee2Bumjin Lim3Dalsan You4Choung-Soo Kim5Department of Urology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, KoreaDepartment of Urology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, KoreaDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaPurpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), were measured in 415 patients diagnosed with prostate cancer. Differences in serum hormone concentrations after receiving androgen deprivation therapy (ADT) and after withdrawal from ADT were evaluated. Pathologic characteristics were assessed in the 225 patients unexposed to ADT with a history of radical prostatectomy. Logistic regression analysis was performed to identify factors predictive of unfavorable pathology (Grade ≥3, ≥T3a, or N1). Results: Of the 415 prostate cancer patients, 130 (31.3%) were assessed before treatment, 171 (41.2%) after surgery, 35 (8.4%) after biochemical recurrence, and 59 (14.2%) during ADT, whereas 20 (4.8%) had castration-resistant prostate cancer. FSH was significantly lower after compared to before prostatectomy (3.229 ± 4.486 vs. 5.941 ± 7.044 mIU/mL, <i>p</i> < 0.001). LH, FSH, and testosterone decreased significantly 3 months after starting ADT, but increased 3 months after ADT withdrawal, whereas SHBG was unchanged. Multivariate analysis showed that high LH (odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.03–2.47, <i>p</i> = 0.0376) and prostate-specific antigen (PSA) (OR: 1.13, 95% CI: 1.03–1.24, <i>p</i> = 0.0133) concentrations were significantly associated with a high risk of unfavorable pathology. Conclusions: Sex hormones, including LH, FSH, and testosterone, were affected by ADT. The FSH level decreased after radical prostatectomy. High baseline LH concentration in patients unexposed to ADT was associated with an unfavorable pathology.https://www.mdpi.com/2077-0383/9/5/1281testosteronesex hormone-binding globulinluteinizing hormonefollicle-stimulating hormoneprostate neoplasms |
| spellingShingle | Se Young Choi Byung Hoon Chi Wonchul Lee Bumjin Lim Dalsan You Choung-Soo Kim Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer Journal of Clinical Medicine testosterone sex hormone-binding globulin luteinizing hormone follicle-stimulating hormone prostate neoplasms |
| title | Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer |
| title_full | Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer |
| title_fullStr | Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer |
| title_full_unstemmed | Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer |
| title_short | Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer |
| title_sort | luteinizing hormone levels relate to the unfavorable pathology of prostate cancer |
| topic | testosterone sex hormone-binding globulin luteinizing hormone follicle-stimulating hormone prostate neoplasms |
| url | https://www.mdpi.com/2077-0383/9/5/1281 |
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