Depression during multiple sclerosis relapse: relation todisability and relapse severity
Aim To examine the presence of depressive symptoms in patients with multiple sclerosis relapse and its relation to disability and relapse severity. Methods This study included 120 patients who were assessed during the acute relapse of multiple sclerosis according to Mc Donald criteria. Depression...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2016-02-01
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| Series: | Medicinski Glasnik |
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| Online Access: | http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/06%20Sabanagic%20Hajric%20839%20A.pdf |
| _version_ | 1818528590814248960 |
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| author | Selma Šabanagić-Hajrić Enra Suljić Gorana Sulejmanpašić-Arslanagić |
| author_facet | Selma Šabanagić-Hajrić Enra Suljić Gorana Sulejmanpašić-Arslanagić |
| author_sort | Selma Šabanagić-Hajrić |
| collection | DOAJ |
| description | Aim To examine the presence of depressive symptoms in patients with multiple sclerosis relapse and its relation to disability and relapse severity.
Methods This study included 120 patients who were assessed during the acute relapse of multiple sclerosis according to Mc Donald criteria. Depression was assessed using Beck Depression Inventory II (BDI-II) calculating both affective and somatic symptom scores. The Expanded Disability Status Scale (EDSS) measured disability. Relapse severity was graded according to the difference between the EDSS score during relapse and EDSS score before the onset of the attack as mild, moderate or severe.
Results There was statistically significant difference between patients with different level of depression considering age (p<0.001), disability (p<0.001), relapse severity (p=0.005) and disease duration (p=0.032). Significant moderate positive correlation of depression with age (rho=0.43) and disability (rho=0.46) was confirmed. There was moderate correlation between disability and somatic symptoms of depression (rho=0.54, p<0.001) with only weak correlation between disability and affective symptoms of depression (rho=0.31, p<0.01). Multiple regression analysis showed that patient’s age and relapse severity (p<0.05) were independently related to depression in these patients while disability did not.
Conclusion Correlation between disability and depression was mostly due to somatic symptoms of depression. Although highly correlated, depression during multiple sclerosis relapse was not independently predicted by disability. Depression should be recognized and treated independently from disability treatment, especially in the group of older patients with more severe relapse. |
| first_indexed | 2024-12-11T06:51:58Z |
| format | Article |
| id | doaj.art-c223b5fb8a76411f97e5de8ef1e7f050 |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-12-11T06:51:58Z |
| publishDate | 2016-02-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-c223b5fb8a76411f97e5de8ef1e7f0502022-12-22T01:16:53ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452016-02-01131444910.17392/839-16Depression during multiple sclerosis relapse: relation todisability and relapse severitySelma Šabanagić-Hajrić0Enra Suljić1Gorana Sulejmanpašić-Arslanagić2Department of Neurology, University Clinical Center Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Psychiatry; University Clinical Center Sarajevo, Sarajevo, Bosnia and HerzegovinaDepartment of Psychiatry; University Clinical Center Sarajevo, Sarajevo, Bosnia and HerzegovinaAim To examine the presence of depressive symptoms in patients with multiple sclerosis relapse and its relation to disability and relapse severity. Methods This study included 120 patients who were assessed during the acute relapse of multiple sclerosis according to Mc Donald criteria. Depression was assessed using Beck Depression Inventory II (BDI-II) calculating both affective and somatic symptom scores. The Expanded Disability Status Scale (EDSS) measured disability. Relapse severity was graded according to the difference between the EDSS score during relapse and EDSS score before the onset of the attack as mild, moderate or severe. Results There was statistically significant difference between patients with different level of depression considering age (p<0.001), disability (p<0.001), relapse severity (p=0.005) and disease duration (p=0.032). Significant moderate positive correlation of depression with age (rho=0.43) and disability (rho=0.46) was confirmed. There was moderate correlation between disability and somatic symptoms of depression (rho=0.54, p<0.001) with only weak correlation between disability and affective symptoms of depression (rho=0.31, p<0.01). Multiple regression analysis showed that patient’s age and relapse severity (p<0.05) were independently related to depression in these patients while disability did not. Conclusion Correlation between disability and depression was mostly due to somatic symptoms of depression. Although highly correlated, depression during multiple sclerosis relapse was not independently predicted by disability. Depression should be recognized and treated independently from disability treatment, especially in the group of older patients with more severe relapse.http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/06%20Sabanagic%20Hajric%20839%20A.pdfmultiple sclerosisdisabilitysomatic symptomsaffective symptoms |
| spellingShingle | Selma Šabanagić-Hajrić Enra Suljić Gorana Sulejmanpašić-Arslanagić Depression during multiple sclerosis relapse: relation todisability and relapse severity Medicinski Glasnik multiple sclerosis disability somatic symptoms affective symptoms |
| title | Depression during multiple sclerosis relapse: relation todisability and relapse severity |
| title_full | Depression during multiple sclerosis relapse: relation todisability and relapse severity |
| title_fullStr | Depression during multiple sclerosis relapse: relation todisability and relapse severity |
| title_full_unstemmed | Depression during multiple sclerosis relapse: relation todisability and relapse severity |
| title_short | Depression during multiple sclerosis relapse: relation todisability and relapse severity |
| title_sort | depression during multiple sclerosis relapse relation todisability and relapse severity |
| topic | multiple sclerosis disability somatic symptoms affective symptoms |
| url | http://www.ljkzedo.ba/sites/default/files/Glasnik/MG24/06%20Sabanagic%20Hajric%20839%20A.pdf |
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