WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer

WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer

Abstract Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor β (ERβ). However, clinical strategies for CRC therapy associated with ERβ are still under investigation. Our discoveries identified WFDC3 as a tumor suppressor that facilitates estr...

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Bibliographic Details
Main Authors:	Tianqi Liu, Min Zhao, Lin Peng, Jiangbo Chen, Pu Xing, Pin Gao, Lei Chen, Xiaowen Qiao, Zaozao Wang, Jiabo Di, Hong Qu, Beihai Jiang, Xiangqian Su
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-07-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-023-05956-0

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