The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect?
Radiofrequency energy is a common treatment modality for chronic pain. While there are different forms of radiofrequency-based therapeutics, the common concept is the generation of an electromagnetic field in the applied area, that can result in neuromodulation (pulsed radiofrequency—PRF) or ablatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11726 |
| _version_ | 1797478925308264448 |
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| author | Daniel de Moraes Ferreira Jorge Stephany Cares Huber Bruno Lima Rodrigues Lucas Furtado Da Fonseca Gabriel Ohana Marques Azzini Carlos Amilcar Parada Christian Paulus-Romero José Fábio Santos Duarte Lana |
| author_facet | Daniel de Moraes Ferreira Jorge Stephany Cares Huber Bruno Lima Rodrigues Lucas Furtado Da Fonseca Gabriel Ohana Marques Azzini Carlos Amilcar Parada Christian Paulus-Romero José Fábio Santos Duarte Lana |
| author_sort | Daniel de Moraes Ferreira Jorge |
| collection | DOAJ |
| description | Radiofrequency energy is a common treatment modality for chronic pain. While there are different forms of radiofrequency-based therapeutics, the common concept is the generation of an electromagnetic field in the applied area, that can result in neuromodulation (pulsed radiofrequency—PRF) or ablation. Our specific focus relates to PRF due to the possibility of modulation that is in accordance with the mechanisms of action of orthobiologics. The proposed mechanism of action of PRF pertaining to pain relief relies on a decrease in pro-inflammatory cytokines, an increase in cytosolic calcium concentration, a general effect on the immune system, and a reduction in the formation of free radical molecules. The primary known properties of orthobiologics constitute the release of growth factors, a stimulus for endogenous repair, analgesia, and improvement of the function of the injured area. In this review, we described the mechanism of action of both treatments and pertinent scientific references to the use of the combination of PRF and orthobiologics. Our hypothesis is a synergic effect with the combination of both techniques which could benefit patients and improve the life quality. |
| first_indexed | 2024-03-09T21:38:33Z |
| format | Article |
| id | doaj.art-c2240248d2d04648a7b21306fb1728de |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:38:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c2240248d2d04648a7b21306fb1728de2023-11-23T20:38:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123191172610.3390/ijms231911726The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect?Daniel de Moraes Ferreira Jorge0Stephany Cares Huber1Bruno Lima Rodrigues2Lucas Furtado Da Fonseca3Gabriel Ohana Marques Azzini4Carlos Amilcar Parada5Christian Paulus-Romero6José Fábio Santos Duarte Lana7Instituto Regenem de Medicina, Rua Bandeira Paulista 716, São Paulo 04532-0021, BrazilOrthoregen International Course—Avenida Presidente Kennedy, 1386, Cidade Nova I, Indaiatuba 13334-170, BrazilOrthoregen International Course—Avenida Presidente Kennedy, 1386, Cidade Nova I, Indaiatuba 13334-170, BrazilOrthopaedic Department, Universidade Federal de São Paulo, 715 Napoleão de Barros St-Vila Clementino, São Paulo 04024-002, BrazilDepartment of Orthopaedics, Brazilian Institute of Regenerative Medicine, Cidade Nova I, Indaiatuba 13334-170, BrazilLaboratory of Study of Pain, Department of Structural and Functional Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas 13083-862, BrazilAmerican Academy of Regenerative Medicine, 14405 West Colfax Avenue, #291, Lakewood, CO 80401, USAOrthoregen International Course—Avenida Presidente Kennedy, 1386, Cidade Nova I, Indaiatuba 13334-170, BrazilRadiofrequency energy is a common treatment modality for chronic pain. While there are different forms of radiofrequency-based therapeutics, the common concept is the generation of an electromagnetic field in the applied area, that can result in neuromodulation (pulsed radiofrequency—PRF) or ablation. Our specific focus relates to PRF due to the possibility of modulation that is in accordance with the mechanisms of action of orthobiologics. The proposed mechanism of action of PRF pertaining to pain relief relies on a decrease in pro-inflammatory cytokines, an increase in cytosolic calcium concentration, a general effect on the immune system, and a reduction in the formation of free radical molecules. The primary known properties of orthobiologics constitute the release of growth factors, a stimulus for endogenous repair, analgesia, and improvement of the function of the injured area. In this review, we described the mechanism of action of both treatments and pertinent scientific references to the use of the combination of PRF and orthobiologics. Our hypothesis is a synergic effect with the combination of both techniques which could benefit patients and improve the life quality.https://www.mdpi.com/1422-0067/23/19/11726pulsed radiofrequencyorthobiologicsneuromodulationgrowth factors |
| spellingShingle | Daniel de Moraes Ferreira Jorge Stephany Cares Huber Bruno Lima Rodrigues Lucas Furtado Da Fonseca Gabriel Ohana Marques Azzini Carlos Amilcar Parada Christian Paulus-Romero José Fábio Santos Duarte Lana The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? International Journal of Molecular Sciences pulsed radiofrequency orthobiologics neuromodulation growth factors |
| title | The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? |
| title_full | The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? |
| title_fullStr | The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? |
| title_full_unstemmed | The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? |
| title_short | The Mechanism of Action between Pulsed Radiofrequency and Orthobiologics: Is There a Synergistic Effect? |
| title_sort | mechanism of action between pulsed radiofrequency and orthobiologics is there a synergistic effect |
| topic | pulsed radiofrequency orthobiologics neuromodulation growth factors |
| url | https://www.mdpi.com/1422-0067/23/19/11726 |
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