Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

Exosomes, nanosized membrane vesicles secreted by cardiac progenitor cells (Exo-CPC), inhibit cardiomyocyte apoptosis under stress conditions, promote angiogenesis in vitro, and prevent the early decline in cardiac function after myocardial infarction in vivo in preclinical rat models. The recogniti...

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Bibliographic Details
Main Authors: Gabriella Andriolo, Elena Provasi, Viviana Lo Cicero, Andrea Brambilla, Sabrina Soncin, Tiziano Torre, Giuseppina Milano, Vanessa Biemmi, Giuseppe Vassalli, Lucia Turchetto, Lucio Barile, Marina Radrizzani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
exosomes
cardiac progenitor cells
good manufacturing practices
large-scale production
quality control
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01169/full

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