Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells

Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells

Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle. The role of hypoxia-inducible factor 2α (HIF-2α) in NAFLD progression remains unknown. This study aimed to investigate the...

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Bibliographic Details
Main Authors: Ranran Yan, Hao Cai, Xiaofeng Zhou, Guodan Bao, Zhenzhong Bai, Ri-li Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
NAFLD/NASH
hepatic stellate cells-derived myofibroblasts
glutaminolysis
HIF-2α
YAP/p-YAP
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1344971/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1344971/full

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