Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom
Background: The mortality of acute aortic dissection (AD) can reach 65~70%. However, it is challenging to follow the progress of AD formation. The purpose of this work was to observe the process of dissection development using a novel tear-embedded silicone phantom. Methods: Silicone phantoms were f...
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MDPI AG
2022-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/290 |
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| author | Qing-Zhuo Chi Yang-Yang Ge Zhen Cao Li-Li Long Li-Zhong Mu Ying He Yong Luan |
| author_facet | Qing-Zhuo Chi Yang-Yang Ge Zhen Cao Li-Li Long Li-Zhong Mu Ying He Yong Luan |
| author_sort | Qing-Zhuo Chi |
| collection | DOAJ |
| description | Background: The mortality of acute aortic dissection (AD) can reach 65~70%. However, it is challenging to follow the progress of AD formation. The purpose of this work was to observe the process of dissection development using a novel tear-embedded silicone phantom. Methods: Silicone phantoms were fabricated by embedding a torn area and primary tear feature on the inner layer. CT scanning and laser lightening were conducted to observe the variations in thickness and volume of the true lumen (TL) and false lumen (FL) during development. Results: The model with a larger interlayer adhesion damage required a lower pressure to trigger the development of dissection. At the initiation stage of dissection, the volume of TL increased by 25.5%, accompanied by a 19.5% enlargement of tear size. The force analysis based on the change of tear size verified the deduction of the process of interlaminar separation from the earlier studies. Conclusions: The primary tear and the weakening adhesion of the vessel layers are key factors in AD development, suggesting that some forms of primary damage to the arterial wall, in particular, the lumen morphology of vessels with straight inner lumen, should be considered as early risk predictors of AD. |
| first_indexed | 2024-03-09T16:16:09Z |
| format | Article |
| id | doaj.art-c22b8710b8684b83b89ac13939f97df8 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:16:09Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c22b8710b8684b83b89ac13939f97df82023-11-24T15:50:54ZengMDPI AGJournal of Functional Biomaterials2079-49832022-12-0113429010.3390/jfb13040290Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone PhantomQing-Zhuo Chi0Yang-Yang Ge1Zhen Cao2Li-Li Long3Li-Zhong Mu4Ying He5Yong Luan6Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian 116024, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaKey Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian 116024, ChinaKey Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian 116024, ChinaKey Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian 116024, ChinaKey Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, Dalian University of Technology, Dalian 116024, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaBackground: The mortality of acute aortic dissection (AD) can reach 65~70%. However, it is challenging to follow the progress of AD formation. The purpose of this work was to observe the process of dissection development using a novel tear-embedded silicone phantom. Methods: Silicone phantoms were fabricated by embedding a torn area and primary tear feature on the inner layer. CT scanning and laser lightening were conducted to observe the variations in thickness and volume of the true lumen (TL) and false lumen (FL) during development. Results: The model with a larger interlayer adhesion damage required a lower pressure to trigger the development of dissection. At the initiation stage of dissection, the volume of TL increased by 25.5%, accompanied by a 19.5% enlargement of tear size. The force analysis based on the change of tear size verified the deduction of the process of interlaminar separation from the earlier studies. Conclusions: The primary tear and the weakening adhesion of the vessel layers are key factors in AD development, suggesting that some forms of primary damage to the arterial wall, in particular, the lumen morphology of vessels with straight inner lumen, should be considered as early risk predictors of AD.https://www.mdpi.com/2079-4983/13/4/2903D printingsilicone phantomCT scanningaortic dissectioninterlayer adhesion damage |
| spellingShingle | Qing-Zhuo Chi Yang-Yang Ge Zhen Cao Li-Li Long Li-Zhong Mu Ying He Yong Luan Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom Journal of Functional Biomaterials 3D printing silicone phantom CT scanning aortic dissection interlayer adhesion damage |
| title | Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom |
| title_full | Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom |
| title_fullStr | Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom |
| title_full_unstemmed | Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom |
| title_short | Experimental Study of the Propagation Process of Dissection Using an Aortic Silicone Phantom |
| title_sort | experimental study of the propagation process of dissection using an aortic silicone phantom |
| topic | 3D printing silicone phantom CT scanning aortic dissection interlayer adhesion damage |
| url | https://www.mdpi.com/2079-4983/13/4/290 |
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