Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer
Background: Colorectal carcinoma (CRC) is the seventh-most common malignancy and is the main cause of death in Iraq. The incidence of this cancer has increased sharply after the invasion of Iraq in 2003. Aim: To estimate immunohistochemical expression of vascular endothelial growth factor (VEGF) in...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2010-04-01
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| Series: | Libyan Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/5059/5550 |
| _version_ | 1818516133653774336 |
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| author | Ali F. Hashim As'ad A. Al-Janabi Liwaa H. Mahdi Kaswer M. Al-Toriahi Akeel A. Yasseen |
| author_facet | Ali F. Hashim As'ad A. Al-Janabi Liwaa H. Mahdi Kaswer M. Al-Toriahi Akeel A. Yasseen |
| author_sort | Ali F. Hashim |
| collection | DOAJ |
| description | Background: Colorectal carcinoma (CRC) is the seventh-most common malignancy and is the main cause of death in Iraq. The incidence of this cancer has increased sharply after the invasion of Iraq in 2003. Aim: To estimate immunohistochemical expression of vascular endothelial growth factor (VEGF) in CRC in relation to other parameters, such as grade and stage of tumour. Methods: Formalin fixed, paraffin-embedded blocks from 52 patients (27 male and 25 female) with CRC were included in this study. A group of 22 patients with non-cancerous colonic tissues were included as a control group. Avidin–biotin complex method was employed for immunohistochemical detection of VEGF. Results: VEGF immuno-expression was positive in 51.9% of CRC, while it was 18.2% in the normal colonic tissue (p<0.05). VEGF immunostaining was positively correlated with grade of colonic malignancy (p<0.05). Conclusion: These findings provide further evidence for the role of VEGF in the carcinogenesis of CRC. However, VEGF could not be well correlated with stage of tumour and hence may be a poor prognostic parameter of state of malignancy of colonic carcinoma. |
| first_indexed | 2024-12-11T00:38:04Z |
| format | Article |
| id | doaj.art-c22c2c78b0124af68c0b6e47aa186edf |
| institution | Directory Open Access Journal |
| issn | 1819-6357 |
| language | English |
| last_indexed | 2024-12-11T00:38:04Z |
| publishDate | 2010-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Libyan Journal of Medicine |
| spelling | doaj.art-c22c2c78b0124af68c0b6e47aa186edf2022-12-22T01:27:04ZengTaylor & Francis GroupLibyan Journal of Medicine1819-63572010-04-01501410.3402/ljm.v5i0.5059Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancerAli F. HashimAs'ad A. Al-JanabiLiwaa H. MahdiKaswer M. Al-ToriahiAkeel A. YasseenBackground: Colorectal carcinoma (CRC) is the seventh-most common malignancy and is the main cause of death in Iraq. The incidence of this cancer has increased sharply after the invasion of Iraq in 2003. Aim: To estimate immunohistochemical expression of vascular endothelial growth factor (VEGF) in CRC in relation to other parameters, such as grade and stage of tumour. Methods: Formalin fixed, paraffin-embedded blocks from 52 patients (27 male and 25 female) with CRC were included in this study. A group of 22 patients with non-cancerous colonic tissues were included as a control group. Avidin–biotin complex method was employed for immunohistochemical detection of VEGF. Results: VEGF immuno-expression was positive in 51.9% of CRC, while it was 18.2% in the normal colonic tissue (p<0.05). VEGF immunostaining was positively correlated with grade of colonic malignancy (p<0.05). Conclusion: These findings provide further evidence for the role of VEGF in the carcinogenesis of CRC. However, VEGF could not be well correlated with stage of tumour and hence may be a poor prognostic parameter of state of malignancy of colonic carcinoma.http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/5059/5550colorectal carcinomaVEGFimmunohistochemistry |
| spellingShingle | Ali F. Hashim As'ad A. Al-Janabi Liwaa H. Mahdi Kaswer M. Al-Toriahi Akeel A. Yasseen Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer Libyan Journal of Medicine colorectal carcinoma VEGF immunohistochemistry |
| title | Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer |
| title_full | Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer |
| title_fullStr | Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer |
| title_full_unstemmed | Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer |
| title_short | Vascular endothelial growth factor (VEGF) receptor expression correlates with histologic grade and stage of colorectal cancer |
| title_sort | vascular endothelial growth factor vegf receptor expression correlates with histologic grade and stage of colorectal cancer |
| topic | colorectal carcinoma VEGF immunohistochemistry |
| url | http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/5059/5550 |
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