TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO

TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO

Abstract Background Ubiquitination plays an important role in proliferating and invasive characteristic of glioblastoma (GBM), similar to many other cancers. Tripartite motif 25 (TRIM25) is a member of the TRIM family of proteins, which are involved in tumorigenesis through substrate ubiquitination....

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Bibliographic Details
Main Authors: Yike Chen, Xiaohui Xu, Kaikai Ding, Tianchi Tang, Feng Cai, Haocheng Zhang, Zihang Chen, Yangjian Qi, Zaixiang Fu, Ganggui Zhu, Zhangqi Dou, Jinfang Xu, Gao Chen, Qun Wu, Jianxiong Ji, Jianmin Zhang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ubiquitination
TRIM25
NONO
Splicing efficiency
c-MYC pathway
Online Access:https://doi.org/10.1186/s13046-024-02964-6

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