Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/249 |
| _version_ | 1797542280018526208 |
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| author | Raquel G. Soengas Humberto Rodríguez-Solla |
| author_facet | Raquel G. Soengas Humberto Rodríguez-Solla |
| author_sort | Raquel G. Soengas |
| collection | DOAJ |
| description | The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry. |
| first_indexed | 2024-03-10T13:27:25Z |
| format | Article |
| id | doaj.art-c22deecd5ba34719b6e6bb0c8d92784e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:27:25Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c22deecd5ba34719b6e6bb0c8d92784e2023-11-21T08:44:18ZengMDPI AGMolecules1420-30492021-01-0126224910.3390/molecules26020249Modern Synthetic Methods for the Stereoselective Construction of 1,3-DienesRaquel G. Soengas0Humberto Rodríguez-Solla1Department of Organic and Inorganic Chemistry, University of Oviedo, Julián Clavería 6, 33006 Oviedo, SpainDepartment of Organic and Inorganic Chemistry, University of Oviedo, Julián Clavería 6, 33006 Oviedo, SpainThe 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry.https://www.mdpi.com/1420-3049/26/2/2491,3-dienesdienylationcross-couplingolefin metathesis |
| spellingShingle | Raquel G. Soengas Humberto Rodríguez-Solla Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes Molecules 1,3-dienes dienylation cross-coupling olefin metathesis |
| title | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
| title_full | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
| title_fullStr | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
| title_full_unstemmed | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
| title_short | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
| title_sort | modern synthetic methods for the stereoselective construction of 1 3 dienes |
| topic | 1,3-dienes dienylation cross-coupling olefin metathesis |
| url | https://www.mdpi.com/1420-3049/26/2/249 |
| work_keys_str_mv | AT raquelgsoengas modernsyntheticmethodsforthestereoselectiveconstructionof13dienes AT humbertorodriguezsolla modernsyntheticmethodsforthestereoselectiveconstructionof13dienes |