Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities
The present report presents a green method for the rapid biogenic synthesis of nanoparticles that offers several advantages over the current chemical and physical procedures. It is easy and fast, eco-friendly, and does not involve any precious elements, hazardous chemicals, or harmful solvents. The...
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/688 |
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| author | Mahesh S. Boya Palajonnala Narasaiah Himabindu B. Balaji G. L. Jangampalli Adi Pradeepkiran Harihara Padhy |
| author_facet | Mahesh S. Boya Palajonnala Narasaiah Himabindu B. Balaji G. L. Jangampalli Adi Pradeepkiran Harihara Padhy |
| author_sort | Mahesh S. |
| collection | DOAJ |
| description | The present report presents a green method for the rapid biogenic synthesis of nanoparticles that offers several advantages over the current chemical and physical procedures. It is easy and fast, eco-friendly, and does not involve any precious elements, hazardous chemicals, or harmful solvents. The synthesized ZnO nanoparticles were characterized using different techniques, such as UV-Visible spectroscopy. The surface plasmon resonance confirmed the formation of ZnO nanoparticles at 344 nm, using UV-Visible spectroscopy. The leaf extract acts as a source of phytochemicals and is primarily used for the reduction and then the formation of stable ZnO nanoparticles by the characteristic functional groups of the extract; the synthesized ZnO nanoparticles were identified using FTIR spectroscopy. The crystalline nature of ZnO-NPs was confirmed via powder X-ray diffraction (XRD). Size and morphology were measured via high resolution transmission electron microscopy (HR-TEM) analysis. The stability of the nanoparticles is established using dynamic light scattering (DLS) and thermogravimetric analysis (TGA). The synthesized ZnO nanoparticles have been found to be a good and efficient catalyst for the synthesis of novel 1,2-dihydro quinazoline derivatives under the green method via a one-pot reaction of 2-amino benzophenone, 1,3-diphenyl-1H-pyrazole carbaldehydes, and ammonium acetate. The synthesized compounds (<b>4a</b>–<b>o</b>) were characterized by the <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS spectra and were further validated for free-radical scavenging activity. The synthesized ZnO nanoparticles exhibited good antioxidant activity. |
| first_indexed | 2024-03-09T11:14:18Z |
| format | Article |
| id | doaj.art-c230f631a4c54738b2228e91c796ebc6 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:18Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c230f631a4c54738b2228e91c796ebc62023-12-01T00:35:06ZengMDPI AGAntioxidants2076-39212022-03-0111468810.3390/antiox11040688Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant ActivitiesMahesh S.0Boya Palajonnala Narasaiah1Himabindu B.2Balaji G. L.3Jangampalli Adi Pradeepkiran4Harihara Padhy5PG&Research Department of Chemistry, Thanthai Hans Roever Collage (Autonomous), Affiliated to Bharathidasan University, Perambalur 621220, IndiaDepartment of Physics, Indian Institute of Technology (IIT), Tirupati 517506, IndiaDepartment of Zoology, Sri Venkateswara University, Tirupati 517502, IndiaPG&Research Department of Chemistry, Thanthai Hans Roever Collage (Autonomous), Affiliated to Bharathidasan University, Perambalur 621220, IndiaDepartment of Zoology, Sri Venkateswara University, Tirupati 517502, IndiaDepartment of Chemistry, School of Advance Science and Languages, VIT Bhopal University, Bhopal 466114, IndiaThe present report presents a green method for the rapid biogenic synthesis of nanoparticles that offers several advantages over the current chemical and physical procedures. It is easy and fast, eco-friendly, and does not involve any precious elements, hazardous chemicals, or harmful solvents. The synthesized ZnO nanoparticles were characterized using different techniques, such as UV-Visible spectroscopy. The surface plasmon resonance confirmed the formation of ZnO nanoparticles at 344 nm, using UV-Visible spectroscopy. The leaf extract acts as a source of phytochemicals and is primarily used for the reduction and then the formation of stable ZnO nanoparticles by the characteristic functional groups of the extract; the synthesized ZnO nanoparticles were identified using FTIR spectroscopy. The crystalline nature of ZnO-NPs was confirmed via powder X-ray diffraction (XRD). Size and morphology were measured via high resolution transmission electron microscopy (HR-TEM) analysis. The stability of the nanoparticles is established using dynamic light scattering (DLS) and thermogravimetric analysis (TGA). The synthesized ZnO nanoparticles have been found to be a good and efficient catalyst for the synthesis of novel 1,2-dihydro quinazoline derivatives under the green method via a one-pot reaction of 2-amino benzophenone, 1,3-diphenyl-1H-pyrazole carbaldehydes, and ammonium acetate. The synthesized compounds (<b>4a</b>–<b>o</b>) were characterized by the <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS spectra and were further validated for free-radical scavenging activity. The synthesized ZnO nanoparticles exhibited good antioxidant activity.https://www.mdpi.com/2076-3921/11/4/688green synthesisZnO-NPs1,2-dihydro quinazolinesantioxidant activity |
| spellingShingle | Mahesh S. Boya Palajonnala Narasaiah Himabindu B. Balaji G. L. Jangampalli Adi Pradeepkiran Harihara Padhy Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities Antioxidants green synthesis ZnO-NPs 1,2-dihydro quinazolines antioxidant activity |
| title | Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities |
| title_full | Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities |
| title_fullStr | Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities |
| title_full_unstemmed | Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities |
| title_short | Sunflower-Assisted Bio-Derived ZnO-NPs as an Efficient Nanocatalyst for the Synthesis of Novel Quinazolines with Highly Antioxidant Activities |
| title_sort | sunflower assisted bio derived zno nps as an efficient nanocatalyst for the synthesis of novel quinazolines with highly antioxidant activities |
| topic | green synthesis ZnO-NPs 1,2-dihydro quinazolines antioxidant activity |
| url | https://www.mdpi.com/2076-3921/11/4/688 |
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