In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents
Cocciniagrandis (Cucurbitaceae) has extensively used to get relief from asthma and cough by the indigenous people of India. The antitussive effect of aerosols of two different concentrations (2.5%, 5%w/v) of methanol extract of C. grandis fruits were tested by counting the numbers of coughs produced...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2009-04-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/1537 |
| _version_ | 1819088144603021312 |
|---|---|
| author | Shakti Prasad Pattanayak Priyashree Sunita |
| author_facet | Shakti Prasad Pattanayak Priyashree Sunita |
| author_sort | Shakti Prasad Pattanayak |
| collection | DOAJ |
| description | Cocciniagrandis (Cucurbitaceae) has extensively used to get relief from asthma and cough by the indigenous people of India. The antitussive effect of aerosols of two different concentrations (2.5%, 5%w/v) of methanol extract of C. grandis fruits were tested by counting the numbers of coughs produced due to aerosols of citric acid, 10 min after exposing the male guinea pigs to aerosols of test solutions for 7 min. In another set of experiment methanol extract was investigated for its therapeutic efficacy on a cough model induced by sulfur dioxide gas in mice. The results showed significant reduction of cough number obtained in the presence of both concentrations of methanol extract as that of the prototype antitussive agent codeine phosphate. Also, methanol extract exhibited significant antitussive effect at 100, 200 and 400 mg/kg, per orally by inhibiting the cough by 20.57, 33.73 and 56.71% within 90 min of performing the experiment. |
| first_indexed | 2024-12-21T21:47:22Z |
| format | Article |
| id | doaj.art-c231b68fd81f4592a21f2d40f6cd7d34 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-21T21:47:22Z |
| publishDate | 2009-04-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-c231b68fd81f4592a21f2d40f6cd7d342022-12-21T18:49:11ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882009-04-014210.3329/bjp.v4i2.1537In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodentsShakti Prasad Pattanayak0Priyashree Sunita1Birla Institute of Technology, Mesra, Ranchi 835215Government Pharmacy Institute, Govt od Jharkhand, Bariatu, Ranchi 834009Cocciniagrandis (Cucurbitaceae) has extensively used to get relief from asthma and cough by the indigenous people of India. The antitussive effect of aerosols of two different concentrations (2.5%, 5%w/v) of methanol extract of C. grandis fruits were tested by counting the numbers of coughs produced due to aerosols of citric acid, 10 min after exposing the male guinea pigs to aerosols of test solutions for 7 min. In another set of experiment methanol extract was investigated for its therapeutic efficacy on a cough model induced by sulfur dioxide gas in mice. The results showed significant reduction of cough number obtained in the presence of both concentrations of methanol extract as that of the prototype antitussive agent codeine phosphate. Also, methanol extract exhibited significant antitussive effect at 100, 200 and 400 mg/kg, per orally by inhibiting the cough by 20.57, 33.73 and 56.71% within 90 min of performing the experiment.https://www.banglajol.info/index.php/BJP/article/view/1537AerosolAntitussiveCoccinia grandisCough |
| spellingShingle | Shakti Prasad Pattanayak Priyashree Sunita In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents Bangladesh Journal of Pharmacology Aerosol Antitussive Coccinia grandis Cough |
| title | In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents |
| title_full | In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents |
| title_fullStr | In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents |
| title_full_unstemmed | In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents |
| title_short | In vivo antitussive activity of Coccinia grandis against irritant aerosol and sulfur dioxide-induced cough model in rodents |
| title_sort | in vivo antitussive activity of coccinia grandis against irritant aerosol and sulfur dioxide induced cough model in rodents |
| topic | Aerosol Antitussive Coccinia grandis Cough |
| url | https://www.banglajol.info/index.php/BJP/article/view/1537 |
| work_keys_str_mv | AT shaktiprasadpattanayak invivoantitussiveactivityofcocciniagrandisagainstirritantaerosolandsulfurdioxideinducedcoughmodelinrodents AT priyashreesunita invivoantitussiveactivityofcocciniagrandisagainstirritantaerosolandsulfurdioxideinducedcoughmodelinrodents |