Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia

Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia

The Gas6–TAM (Tyro3, Axl, Mer) ligand–receptor system is believed to promote central nervous system (CNS) (re)myelination and glial cell development. An additional important function of Gas6–TAM signalling appears to be the regulation of immunity and inflammation, which remains to be fully elucidate...

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Bibliographic Details
Main Authors: Salman Goudarzi, Shannon E. Gilchrist, Sassan Hafizi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
IL-10
TGF-β
Gas6
TAM receptor
optic nerve
vitamin K
Online Access:https://www.mdpi.com/2073-4409/9/8/1779

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