Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Colorectal cancer (CRC) is the second most prevalent type of cancer in Europe. Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality. Colonoscopy and computed tomography colonography...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-05-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/10/47 |
| _version_ | 1811267271285276672 |
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| author | van Leerdam Monique E Essink-Bot Marie-Louise van Ballegooijen Marjolein Thomeer Maarten Bossuyt Patrick MM Fockens Paul Deutekom Marije Stoop Esther M de Haan Margriet C de Wijkerslooth Thomas R Kuipers Ernst J Dekker Evelien Stoker Jaap |
| author_facet | van Leerdam Monique E Essink-Bot Marie-Louise van Ballegooijen Marjolein Thomeer Maarten Bossuyt Patrick MM Fockens Paul Deutekom Marije Stoop Esther M de Haan Margriet C de Wijkerslooth Thomas R Kuipers Ernst J Dekker Evelien Stoker Jaap |
| author_sort | van Leerdam Monique E |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Colorectal cancer (CRC) is the second most prevalent type of cancer in Europe. Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality. Colonoscopy and computed tomography colonography (CT colonography) are highly accurate exams and screening options that examine the entire colon. The success of screening depends on the participation rate. We designed a randomized trial to compare the uptake, yield and costs of direct colonoscopy population screening, using either a telephone consultation or a consultation at the outpatient clinic, versus CT colonography first, with colonoscopy in CT colonography positives.</p> <p>Methods and design</p> <p>7,500 persons between 50 and 75 years will be randomly selected from the electronic database of the municipal administration registration and will receive an invitation to participate in either CT colonography (2,500 persons) or colonoscopy (5,000 persons) screening. Those invited for colonoscopy screening will be randomized to a prior consultation either by telephone or a visit at the outpatient clinic. All CT colonography invitees will have a prior consultation by telephone. Invitees are instructed to consult their general practitioner and not to participate in screening if they have symptoms suggestive for CRC. After providing informed consent, participants will be scheduled for the screening procedure. The primary outcome measure of this study is the participation rate. Secondary outcomes are the diagnostic yield, the expected and perceived burden of the screening test, level of informed choice and cost-effectiveness of both screening methods.</p> <p>Discussion</p> <p>This study will provide further evidence to enable decision making in population screening for colorectal cancer.</p> <p>Trial registration</p> <p>Dutch trial register: NTR1829</p> |
| first_indexed | 2024-04-12T20:58:25Z |
| format | Article |
| id | doaj.art-c233db2c281247b7861030505bc27d40 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T20:58:25Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-c233db2c281247b7861030505bc27d402022-12-22T03:16:54ZengBMCBMC Gastroenterology1471-230X2010-05-011014710.1186/1471-230X-10-47Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trialvan Leerdam Monique EEssink-Bot Marie-Louisevan Ballegooijen MarjoleinThomeer MaartenBossuyt Patrick MMFockens PaulDeutekom MarijeStoop Esther Mde Haan Margriet Cde Wijkerslooth Thomas RKuipers Ernst JDekker EvelienStoker Jaap<p>Abstract</p> <p>Background</p> <p>Colorectal cancer (CRC) is the second most prevalent type of cancer in Europe. Early detection and removal of CRC or its precursor lesions by population screening can reduce mortality. Colonoscopy and computed tomography colonography (CT colonography) are highly accurate exams and screening options that examine the entire colon. The success of screening depends on the participation rate. We designed a randomized trial to compare the uptake, yield and costs of direct colonoscopy population screening, using either a telephone consultation or a consultation at the outpatient clinic, versus CT colonography first, with colonoscopy in CT colonography positives.</p> <p>Methods and design</p> <p>7,500 persons between 50 and 75 years will be randomly selected from the electronic database of the municipal administration registration and will receive an invitation to participate in either CT colonography (2,500 persons) or colonoscopy (5,000 persons) screening. Those invited for colonoscopy screening will be randomized to a prior consultation either by telephone or a visit at the outpatient clinic. All CT colonography invitees will have a prior consultation by telephone. Invitees are instructed to consult their general practitioner and not to participate in screening if they have symptoms suggestive for CRC. After providing informed consent, participants will be scheduled for the screening procedure. The primary outcome measure of this study is the participation rate. Secondary outcomes are the diagnostic yield, the expected and perceived burden of the screening test, level of informed choice and cost-effectiveness of both screening methods.</p> <p>Discussion</p> <p>This study will provide further evidence to enable decision making in population screening for colorectal cancer.</p> <p>Trial registration</p> <p>Dutch trial register: NTR1829</p>http://www.biomedcentral.com/1471-230X/10/47 |
| spellingShingle | van Leerdam Monique E Essink-Bot Marie-Louise van Ballegooijen Marjolein Thomeer Maarten Bossuyt Patrick MM Fockens Paul Deutekom Marije Stoop Esther M de Haan Margriet C de Wijkerslooth Thomas R Kuipers Ernst J Dekker Evelien Stoker Jaap Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial BMC Gastroenterology |
| title | Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial |
| title_full | Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial |
| title_fullStr | Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial |
| title_full_unstemmed | Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial |
| title_short | Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial |
| title_sort | study protocol population screening for colorectal cancer by colonoscopy or ct colonography a randomized controlled trial |
| url | http://www.biomedcentral.com/1471-230X/10/47 |
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