Presence of complete murine viral genome sequences in patient-derived xenografts
Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22200-5 |
| _version_ | 1818845609010921472 |
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| author | Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng |
| author_facet | Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng |
| author_sort | Zihao Yuan |
| collection | DOAJ |
| description | Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples with high virus load. |
| first_indexed | 2024-12-19T05:32:22Z |
| format | Article |
| id | doaj.art-c239a456dafd4db3ab6b1fee821051bc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:32:22Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c239a456dafd4db3ab6b1fee821051bc2022-12-21T20:34:13ZengNature PortfolioNature Communications2041-17232021-04-0112111110.1038/s41467-021-22200-5Presence of complete murine viral genome sequences in patient-derived xenograftsZihao Yuan0Xuejun Fan1Jay-Jiguang Zhu2Tong-Ming Fu3Jiaqian Wu4Hua Xu5Ningyan Zhang6Zhiqiang An7W. Jim Zheng8School of Biomedical Informatics, University of Texas Health Science Center at HoustonTexas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonDepartment of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at HoustonTexas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonDepartment of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at HoustonSchool of Biomedical Informatics, University of Texas Health Science Center at HoustonTexas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTexas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonSchool of Biomedical Informatics, University of Texas Health Science Center at HoustonPatient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and significant expression change of crucial genes in samples with high virus load.https://doi.org/10.1038/s41467-021-22200-5 |
| spellingShingle | Zihao Yuan Xuejun Fan Jay-Jiguang Zhu Tong-Ming Fu Jiaqian Wu Hua Xu Ningyan Zhang Zhiqiang An W. Jim Zheng Presence of complete murine viral genome sequences in patient-derived xenografts Nature Communications |
| title | Presence of complete murine viral genome sequences in patient-derived xenografts |
| title_full | Presence of complete murine viral genome sequences in patient-derived xenografts |
| title_fullStr | Presence of complete murine viral genome sequences in patient-derived xenografts |
| title_full_unstemmed | Presence of complete murine viral genome sequences in patient-derived xenografts |
| title_short | Presence of complete murine viral genome sequences in patient-derived xenografts |
| title_sort | presence of complete murine viral genome sequences in patient derived xenografts |
| url | https://doi.org/10.1038/s41467-021-22200-5 |
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