Factors Affecting the Tissue Damaging Consequences of Viral Infections
Humans and animals are infected by multiple endogenous and exogenous viruses but few agents cause overt tissue damage. We review the circumstances which favor overt disease expression. These can include intrinsic virulence of the agent, new agents acquired from heterologous species, the circumstance...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.02314/full |
| _version_ | 1818508824075567104 |
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| author | Deepak Sumbria Engin Berber Barry T. Rouse |
| author_facet | Deepak Sumbria Engin Berber Barry T. Rouse |
| author_sort | Deepak Sumbria |
| collection | DOAJ |
| description | Humans and animals are infected by multiple endogenous and exogenous viruses but few agents cause overt tissue damage. We review the circumstances which favor overt disease expression. These can include intrinsic virulence of the agent, new agents acquired from heterologous species, the circumstances of infection such as dose and route, current infection with other agents which includes the composition of the microbiome at mucosal and other sites, past history of exposure to other infections as well as the immune status of the host. We also briefly discuss promising therapeutic strategies that can expand immune response patterns that minimize tissue damaging responses to viral infections. |
| first_indexed | 2024-12-10T22:37:11Z |
| format | Article |
| id | doaj.art-c239f45b85e64a379c74e86186fb3e8b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T22:37:11Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-c239f45b85e64a379c74e86186fb3e8b2022-12-22T01:30:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-10-011010.3389/fmicb.2019.02314488059Factors Affecting the Tissue Damaging Consequences of Viral InfectionsDeepak SumbriaEngin BerberBarry T. RouseHumans and animals are infected by multiple endogenous and exogenous viruses but few agents cause overt tissue damage. We review the circumstances which favor overt disease expression. These can include intrinsic virulence of the agent, new agents acquired from heterologous species, the circumstances of infection such as dose and route, current infection with other agents which includes the composition of the microbiome at mucosal and other sites, past history of exposure to other infections as well as the immune status of the host. We also briefly discuss promising therapeutic strategies that can expand immune response patterns that minimize tissue damaging responses to viral infections.https://www.frontiersin.org/article/10.3389/fmicb.2019.02314/fullviral infectionimmunopathologyoutcome of past and concomitant infectionsinfluence of microbiome and virometherapeutic management of infections |
| spellingShingle | Deepak Sumbria Engin Berber Barry T. Rouse Factors Affecting the Tissue Damaging Consequences of Viral Infections Frontiers in Microbiology viral infection immunopathology outcome of past and concomitant infections influence of microbiome and virome therapeutic management of infections |
| title | Factors Affecting the Tissue Damaging Consequences of Viral Infections |
| title_full | Factors Affecting the Tissue Damaging Consequences of Viral Infections |
| title_fullStr | Factors Affecting the Tissue Damaging Consequences of Viral Infections |
| title_full_unstemmed | Factors Affecting the Tissue Damaging Consequences of Viral Infections |
| title_short | Factors Affecting the Tissue Damaging Consequences of Viral Infections |
| title_sort | factors affecting the tissue damaging consequences of viral infections |
| topic | viral infection immunopathology outcome of past and concomitant infections influence of microbiome and virome therapeutic management of infections |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.02314/full |
| work_keys_str_mv | AT deepaksumbria factorsaffectingthetissuedamagingconsequencesofviralinfections AT enginberber factorsaffectingthetissuedamagingconsequencesofviralinfections AT barrytrouse factorsaffectingthetissuedamagingconsequencesofviralinfections |