Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research
Background Antiretroviral therapy (ART) may influence individuals who do not receive the intervention but who are connected in some way to the person who does. Relatively little is known, however, about the size and scope of, what we term, spillover effects of ART. We explored intergenerational spil...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Global Health |
| Online Access: | https://gh.bmj.com/content/8/4/e011079.full |
| _version_ | 1797845289582723072 |
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| author | Till Bärnighausen Francesc Xavier Gómez-Olivé Janet Seeley Jan-Walter De Neve Harsha Thirumurthy Henning Schröder H. Manisha Yapa |
| author_facet | Till Bärnighausen Francesc Xavier Gómez-Olivé Janet Seeley Jan-Walter De Neve Harsha Thirumurthy Henning Schröder H. Manisha Yapa |
| author_sort | Till Bärnighausen |
| collection | DOAJ |
| description | Background Antiretroviral therapy (ART) may influence individuals who do not receive the intervention but who are connected in some way to the person who does. Relatively little is known, however, about the size and scope of, what we term, spillover effects of ART. We explored intergenerational spillover effects of ART in sub-Saharan Africa (SSA) and identified several directions for future research.Methods We conducted a scoping review between March and April 2022. We systematically searched PubMed, PsycINFO, EconLit, OTseeker, AIDSInfo, Web of Science, CINHAL, Google Scholar and African Index Medicus. We analysed the distribution of included studies over time and summarised their findings. We examined the intergenerational impact of ART provision to working-age adults living with HIV on children (‘downward’ spillover effects) and older adults (‘upward’ spillover effects). We categorised types of intergenerational spillover effects according to broad themes which emerged from our analysis of included studies.Findings We identified 26 studies published between 2005 and 2022 with 16 studies assessing spillover effects from adults to children (downward), and 1 study explicitly assessing spillover effects from working-age adults to older adults (upward). The remaining studies did not fully specify the direction of spillover effects. Most spillover effects of ART to household and family members were beneficial and included improvements in wealth, labour market outcomes, health outcomes and health services utilisation, schooling, and household composition. Both children and older adults benefited from ART availability among adults. Detrimental spillover effects were only reported in three studies and included financial and opportunity costs associated with health services utilisation and food insecurity in the first year after ART.Conclusions ART may lead to substantial spillover effects across generations and sectors in SSA. Further research is needed to capitalise on positive spillover effects while mitigating potential negative spillover effects. The returns to investments in large-scale health interventions such as ART may be underestimated without considering these societal benefits. |
| first_indexed | 2024-04-09T17:37:44Z |
| format | Article |
| id | doaj.art-c23be48756af44e99ebf822f36b933e4 |
| institution | Directory Open Access Journal |
| issn | 2059-7908 |
| language | English |
| last_indexed | 2024-04-09T17:37:44Z |
| publishDate | 2023-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Global Health |
| spelling | doaj.art-c23be48756af44e99ebf822f36b933e42023-04-17T15:00:06ZengBMJ Publishing GroupBMJ Global Health2059-79082023-04-018410.1136/bmjgh-2022-011079Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for researchTill Bärnighausen0Francesc Xavier Gómez-Olivé1Janet Seeley2Jan-Walter De Neve3Harsha Thirumurthy4Henning Schröder5H. Manisha Yapa6Harvard Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts, USASouth African Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaMedical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, UgandaHeidelberg Institute of Global Health, Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, GermanyDepartment of Medical Ethics and Health Policy, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PennsylvaniaHeidelberg Institute of Global Health, Medical Faculty, Heidelberg University, Heidelberg, GermanyWestmead Clinical School, The University of Sydney, Sydney, New South Wales, AustraliaBackground Antiretroviral therapy (ART) may influence individuals who do not receive the intervention but who are connected in some way to the person who does. Relatively little is known, however, about the size and scope of, what we term, spillover effects of ART. We explored intergenerational spillover effects of ART in sub-Saharan Africa (SSA) and identified several directions for future research.Methods We conducted a scoping review between March and April 2022. We systematically searched PubMed, PsycINFO, EconLit, OTseeker, AIDSInfo, Web of Science, CINHAL, Google Scholar and African Index Medicus. We analysed the distribution of included studies over time and summarised their findings. We examined the intergenerational impact of ART provision to working-age adults living with HIV on children (‘downward’ spillover effects) and older adults (‘upward’ spillover effects). We categorised types of intergenerational spillover effects according to broad themes which emerged from our analysis of included studies.Findings We identified 26 studies published between 2005 and 2022 with 16 studies assessing spillover effects from adults to children (downward), and 1 study explicitly assessing spillover effects from working-age adults to older adults (upward). The remaining studies did not fully specify the direction of spillover effects. Most spillover effects of ART to household and family members were beneficial and included improvements in wealth, labour market outcomes, health outcomes and health services utilisation, schooling, and household composition. Both children and older adults benefited from ART availability among adults. Detrimental spillover effects were only reported in three studies and included financial and opportunity costs associated with health services utilisation and food insecurity in the first year after ART.Conclusions ART may lead to substantial spillover effects across generations and sectors in SSA. Further research is needed to capitalise on positive spillover effects while mitigating potential negative spillover effects. The returns to investments in large-scale health interventions such as ART may be underestimated without considering these societal benefits.https://gh.bmj.com/content/8/4/e011079.full |
| spellingShingle | Till Bärnighausen Francesc Xavier Gómez-Olivé Janet Seeley Jan-Walter De Neve Harsha Thirumurthy Henning Schröder H. Manisha Yapa Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research BMJ Global Health |
| title | Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research |
| title_full | Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research |
| title_fullStr | Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research |
| title_full_unstemmed | Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research |
| title_short | Intergenerational spillover effects of antiretroviral therapy in sub-Saharan Africa: a scoping review and future directions for research |
| title_sort | intergenerational spillover effects of antiretroviral therapy in sub saharan africa a scoping review and future directions for research |
| url | https://gh.bmj.com/content/8/4/e011079.full |
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