Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review
Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim of this study is to evaluate the effectiveness of autologous tooth as a grafting material and examine the properties of this material and i...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/14/3/132 |
| _version_ | 1797610974656593920 |
|---|---|
| author | Angelo Michele Inchingolo Assunta Patano Chiara Di Pede Alessio Danilo Inchingolo Giulia Palmieri Elisabetta de Ruvo Merigrazia Campanelli Silvio Buongiorno Vincenzo Carpentiere Fabio Piras Vito Settanni Fabio Viapiano Denisa Hazballa Biagio Rapone Antonio Mancini Daniela Di Venere Francesco Inchingolo Maria Celeste Fatone Andrea Palermo Elio Minetti Felice Lorusso Antonio Scarano Salvatore Sauro Gianluca Martino Tartaglia Ioana Roxana Bordea Gianna Dipalma Giuseppina Malcangi |
| author_facet | Angelo Michele Inchingolo Assunta Patano Chiara Di Pede Alessio Danilo Inchingolo Giulia Palmieri Elisabetta de Ruvo Merigrazia Campanelli Silvio Buongiorno Vincenzo Carpentiere Fabio Piras Vito Settanni Fabio Viapiano Denisa Hazballa Biagio Rapone Antonio Mancini Daniela Di Venere Francesco Inchingolo Maria Celeste Fatone Andrea Palermo Elio Minetti Felice Lorusso Antonio Scarano Salvatore Sauro Gianluca Martino Tartaglia Ioana Roxana Bordea Gianna Dipalma Giuseppina Malcangi |
| author_sort | Angelo Michele Inchingolo |
| collection | DOAJ |
| description | Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim of this study is to evaluate the effectiveness of autologous tooth as a grafting material and examine the properties of this material and its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, and Web of Science were searched to find articles addressing our topic published from 1 January 2012 up to 22 November 2022, and a total of 1516 studies were identified. Eighteen papers in all were considered in this review for qualitative analysis. Demineralized dentin can be used as a graft material, since it shows high cell compatibility and promotes rapid bone regeneration by striking an ideal balance between bone resorption and production; it also has several benefits, such as quick recovery times, high-quality newly formed bone, low costs, no risk of disease transmission, the ability to be performed as an outpatient procedure, and no donor-related postoperative complications. Demineralization is a crucial step in the tooth treatment process, which includes cleaning, grinding, and demineralization. Since the presence of hydroxyapatite crystals prevents the release of growth factors, demineralization is essential for effective regenerative surgery. Even though the relationship between the bone system and dysbiosis has not yet been fully explored, this study highlights an association between bone and gut microbes. The creation of additional scientific studies to build upon and enhance the findings of this study should be a future objective of scientific research. |
| first_indexed | 2024-03-11T06:21:30Z |
| format | Article |
| id | doaj.art-c23c54deec714c6c9e4c5917833c625d |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T06:21:30Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-c23c54deec714c6c9e4c5917833c625d2023-11-17T11:54:02ZengMDPI AGJournal of Functional Biomaterials2079-49832023-02-0114313210.3390/jfb14030132Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic ReviewAngelo Michele Inchingolo0Assunta Patano1Chiara Di Pede2Alessio Danilo Inchingolo3Giulia Palmieri4Elisabetta de Ruvo5Merigrazia Campanelli6Silvio Buongiorno7Vincenzo Carpentiere8Fabio Piras9Vito Settanni10Fabio Viapiano11Denisa Hazballa12Biagio Rapone13Antonio Mancini14Daniela Di Venere15Francesco Inchingolo16Maria Celeste Fatone17Andrea Palermo18Elio Minetti19Felice Lorusso20Antonio Scarano21Salvatore Sauro22Gianluca Martino Tartaglia23Ioana Roxana Bordea24Gianna Dipalma25Giuseppina Malcangi26Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyPTA Trani-ASL BT, Viale Padre Pio, 76125 Trani, ItalyCollege of Medicine and Dentistry Birmingham, University of Birmingham, Birmingham B4 6BN, UKDepartment of Biomedical, Surgical, and Dental Science, Università Degli Studi di Milano, 20122 Milan, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, 20100 Milan, ItalyDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDifferent biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim of this study is to evaluate the effectiveness of autologous tooth as a grafting material and examine the properties of this material and its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, and Web of Science were searched to find articles addressing our topic published from 1 January 2012 up to 22 November 2022, and a total of 1516 studies were identified. Eighteen papers in all were considered in this review for qualitative analysis. Demineralized dentin can be used as a graft material, since it shows high cell compatibility and promotes rapid bone regeneration by striking an ideal balance between bone resorption and production; it also has several benefits, such as quick recovery times, high-quality newly formed bone, low costs, no risk of disease transmission, the ability to be performed as an outpatient procedure, and no donor-related postoperative complications. Demineralization is a crucial step in the tooth treatment process, which includes cleaning, grinding, and demineralization. Since the presence of hydroxyapatite crystals prevents the release of growth factors, demineralization is essential for effective regenerative surgery. Even though the relationship between the bone system and dysbiosis has not yet been fully explored, this study highlights an association between bone and gut microbes. The creation of additional scientific studies to build upon and enhance the findings of this study should be a future objective of scientific research.https://www.mdpi.com/2079-4983/14/3/132tooth transformer<sup>®</sup>biomaterialsautologous grafttooth graftdemineralized dentine matrixmicrobiota |
| spellingShingle | Angelo Michele Inchingolo Assunta Patano Chiara Di Pede Alessio Danilo Inchingolo Giulia Palmieri Elisabetta de Ruvo Merigrazia Campanelli Silvio Buongiorno Vincenzo Carpentiere Fabio Piras Vito Settanni Fabio Viapiano Denisa Hazballa Biagio Rapone Antonio Mancini Daniela Di Venere Francesco Inchingolo Maria Celeste Fatone Andrea Palermo Elio Minetti Felice Lorusso Antonio Scarano Salvatore Sauro Gianluca Martino Tartaglia Ioana Roxana Bordea Gianna Dipalma Giuseppina Malcangi Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review Journal of Functional Biomaterials tooth transformer<sup>®</sup> biomaterials autologous graft tooth graft demineralized dentine matrix microbiota |
| title | Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review |
| title_full | Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review |
| title_fullStr | Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review |
| title_full_unstemmed | Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review |
| title_short | Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer<sup>®</sup> and the Role of Microbiota in Regenerative Dentistry. A Systematic Review |
| title_sort | autologous tooth graft innovative biomaterial for bone regeneration tooth transformer sup r sup and the role of microbiota in regenerative dentistry a systematic review |
| topic | tooth transformer<sup>®</sup> biomaterials autologous graft tooth graft demineralized dentine matrix microbiota |
| url | https://www.mdpi.com/2079-4983/14/3/132 |
| work_keys_str_mv | AT angelomicheleinchingolo autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT assuntapatano autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT chiaradipede autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT alessiodaniloinchingolo autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT giuliapalmieri autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT elisabettaderuvo autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT merigraziacampanelli autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT silviobuongiorno autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT vincenzocarpentiere autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT fabiopiras autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT vitosettanni autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT fabioviapiano autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT denisahazballa autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT biagiorapone autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT antoniomancini autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT danieladivenere autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT francescoinchingolo autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT mariacelestefatone autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT andreapalermo autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT eliominetti autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT felicelorusso autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT antonioscarano autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT salvatoresauro autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT gianlucamartinotartaglia autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT ioanaroxanabordea autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT giannadipalma autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview AT giuseppinamalcangi autologoustoothgraftinnovativebiomaterialforboneregenerationtoothtransformersupsupandtheroleofmicrobiotainregenerativedentistryasystematicreview |