Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight
Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; ev...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-06-01
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| Series: | Journal of Family and Reproductive Health |
| Subjects: | |
| Online Access: | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1622 |
| _version_ | 1818975837872979968 |
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| author | Amrita Talwar Pushpanjali Behera Arvind Ahuja Bani Sarkar Ravi Hari Phulware |
| author_facet | Amrita Talwar Pushpanjali Behera Arvind Ahuja Bani Sarkar Ravi Hari Phulware |
| author_sort | Amrita Talwar |
| collection | DOAJ |
| description | Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma.
Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described.
Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity. |
| first_indexed | 2024-12-20T16:02:18Z |
| format | Article |
| id | doaj.art-c23cf2f91ca74a89954894674d020715 |
| institution | Directory Open Access Journal |
| issn | 1735-8949 1735-9392 |
| language | English |
| last_indexed | 2024-12-20T16:02:18Z |
| publishDate | 2021-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Family and Reproductive Health |
| spelling | doaj.art-c23cf2f91ca74a89954894674d0207152022-12-21T19:34:15ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922021-06-0115210.18502/jfrh.v15i2.6454Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological InsightAmrita Talwar0Pushpanjali Behera1Arvind Ahuja2Bani Sarkar3Ravi Hari Phulware4Department of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, IndiaDepartment of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, IndiaDepartment of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, IndiaDepartment of Obstetrics & Gynecology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, IndiaDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, IndiaObjective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma. Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described. Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1622Endometrial NeoplasmsAdenomyosisMenopauseCarcinoma in SituEndometriumCarcinoma |
| spellingShingle | Amrita Talwar Pushpanjali Behera Arvind Ahuja Bani Sarkar Ravi Hari Phulware Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight Journal of Family and Reproductive Health Endometrial Neoplasms Adenomyosis Menopause Carcinoma in Situ Endometrium Carcinoma |
| title | Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight |
| title_full | Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight |
| title_fullStr | Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight |
| title_full_unstemmed | Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight |
| title_short | Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight |
| title_sort | endometrial serous carcinoma arising from adenomyosis a clinico pathological insight |
| topic | Endometrial Neoplasms Adenomyosis Menopause Carcinoma in Situ Endometrium Carcinoma |
| url | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1622 |
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