ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20357-z |
| _version_ | 1818996916748288000 |
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| author | Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak |
| author_facet | Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak |
| author_sort | Hayley I. Muendlein |
| collection | DOAJ |
| description | Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1. |
| first_indexed | 2024-12-20T21:37:21Z |
| format | Article |
| id | doaj.art-c23eacb750254746b5eeb2cdfdaf0689 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:37:21Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c23eacb750254746b5eeb2cdfdaf06892022-12-21T19:25:54ZengNature PortfolioNature Communications2041-17232021-01-0112111310.1038/s41467-020-20357-zZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1Hayley I. Muendlein0Wilson M. Connolly1Zoie Magri2Irina Smirnova3Vladimir Ilyukha4Avishekh Gautam5Alexei Degterev6Alexander Poltorak7Department of Immunology, Tufts University School of MedicineDepartment of Immunology, Tufts University School of MedicineDepartment of Immunology, Tufts University School of MedicineDepartment of Immunology, Tufts University School of MedicinePetrozavodsk State UlniversityBlood Cell Development and Function Program, Fox Chase Cancer CenterDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of MedicineDepartment of Immunology, Tufts University School of MedicineYersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.https://doi.org/10.1038/s41467-020-20357-z |
| spellingShingle | Hayley I. Muendlein Wilson M. Connolly Zoie Magri Irina Smirnova Vladimir Ilyukha Avishekh Gautam Alexei Degterev Alexander Poltorak ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 Nature Communications |
| title | ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 |
| title_full | ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 |
| title_fullStr | ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 |
| title_full_unstemmed | ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 |
| title_short | ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1 |
| title_sort | zbp1 promotes lps induced cell death and il 1β release via rhim mediated interactions with ripk1 |
| url | https://doi.org/10.1038/s41467-020-20357-z |
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