Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia
Owing to the rarity and the biological and clinical heterogeneity of gastroenteropancreatic neuroendocrine neoplasia (GEP NEN), the management of these patients may be challenging for physicians. This review highlights the specific features of GEP NEN with particular attention on the role of Ki67 he...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Endocrines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-396X/2/1/3 |
| _version_ | 1827598175573114880 |
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| author | Ludovica Magi Maria Rinzivillo Francesco Panzuto |
| author_facet | Ludovica Magi Maria Rinzivillo Francesco Panzuto |
| author_sort | Ludovica Magi |
| collection | DOAJ |
| description | Owing to the rarity and the biological and clinical heterogeneity of gastroenteropancreatic neuroendocrine neoplasia (GEP NEN), the management of these patients may be challenging for physicians. This review highlights the specific features of GEP NEN with particular attention on the role of Ki67 heterogeneity, the potential prognostic role of novel radiological techniques, and the clinical usefulness of functional imaging, including 68Ga-DOTA-SST PET/CT and 18F-FDG PET/CT. Understanding these specific features may help to plan proper and tailored follow-up programs and therapeutic approaches. |
| first_indexed | 2024-03-09T03:45:51Z |
| format | Article |
| id | doaj.art-c23f742f56474ba3a51a80e4564bdab2 |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-09T03:45:51Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-c23f742f56474ba3a51a80e4564bdab22023-12-03T14:35:37ZengMDPI AGEndocrines2673-396X2021-01-0121283610.3390/endocrines2010003Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine NeoplasiaLudovica Magi0Maria Rinzivillo1Francesco Panzuto2SAIMLAL Department (Human Anatomy, Histology, Forensic Medicine and Orthopedics), Sapienza University of Rome, 00185 Rome, ItalyDigestive Disease Unit, Sant’Andrea University Hospital—ENETS Center of Excellence of Via di Grottarossa, 1035, 00189 Rome, ItalyDigestive Disease Unit, Sant’Andrea University Hospital—ENETS Center of Excellence of Via di Grottarossa, 1035, 00189 Rome, ItalyOwing to the rarity and the biological and clinical heterogeneity of gastroenteropancreatic neuroendocrine neoplasia (GEP NEN), the management of these patients may be challenging for physicians. This review highlights the specific features of GEP NEN with particular attention on the role of Ki67 heterogeneity, the potential prognostic role of novel radiological techniques, and the clinical usefulness of functional imaging, including 68Ga-DOTA-SST PET/CT and 18F-FDG PET/CT. Understanding these specific features may help to plan proper and tailored follow-up programs and therapeutic approaches.https://www.mdpi.com/2673-396X/2/1/3neuroendocrine tumorsKi67carcinoidssomatostatin analogsradiomicpositron emission tomography |
| spellingShingle | Ludovica Magi Maria Rinzivillo Francesco Panzuto Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia Endocrines neuroendocrine tumors Ki67 carcinoids somatostatin analogs radiomic positron emission tomography |
| title | Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia |
| title_full | Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia |
| title_fullStr | Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia |
| title_full_unstemmed | Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia |
| title_short | Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia |
| title_sort | tumor heterogenity in gastro entero pancreatic neuroendocrine neoplasia |
| topic | neuroendocrine tumors Ki67 carcinoids somatostatin analogs radiomic positron emission tomography |
| url | https://www.mdpi.com/2673-396X/2/1/3 |
| work_keys_str_mv | AT ludovicamagi tumorheterogenityingastroenteropancreaticneuroendocrineneoplasia AT mariarinzivillo tumorheterogenityingastroenteropancreaticneuroendocrineneoplasia AT francescopanzuto tumorheterogenityingastroenteropancreaticneuroendocrineneoplasia |