Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report
Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Contemporary Clinical Dentistry |
| Subjects: | |
| Online Access: | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2012;volume=3;issue=1;spage=74;epage=77;aulast=Grewal |
| _version_ | 1818941990269616128 |
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| author | Partapjot S Grewal Kanu Priya Gupta |
| author_facet | Partapjot S Grewal Kanu Priya Gupta |
| author_sort | Partapjot S Grewal |
| collection | DOAJ |
| description | Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization and rachitic changes in the metaphases, stress fractures, chondrocalcinosis and osteoarthropathy. Characteristic dental symptoms include premature loss of deciduous teeth, premature exfoliation of fully rooted permanent teeth, severe dental caries and alveolar bone loss. This clinical report describes the prosthetic rehabilitation of a sixteen year old female patient with hypophosphatasia with partial anodontia and no occlusion. Patient was managed clinically by saving her remaining teeth, fabricating a maxillary overdenture and mandibular cast partial denture. This not only helped her functionally in biting and chewing food and achieving a good occlusion, but also restored her confidence and self image by improving the aesthetics. |
| first_indexed | 2024-12-20T07:04:19Z |
| format | Article |
| id | doaj.art-c2402ee7b10d4c19a999295ff51239e5 |
| institution | Directory Open Access Journal |
| issn | 0976-237X 0976-2361 |
| language | English |
| last_indexed | 2024-12-20T07:04:19Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Contemporary Clinical Dentistry |
| spelling | doaj.art-c2402ee7b10d4c19a999295ff51239e52022-12-21T19:49:07ZengWolters Kluwer Medknow PublicationsContemporary Clinical Dentistry0976-237X0976-23612012-01-0131747710.4103/0976-237X.94551Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case reportPartapjot S GrewalKanu Priya GuptaHypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization and rachitic changes in the metaphases, stress fractures, chondrocalcinosis and osteoarthropathy. Characteristic dental symptoms include premature loss of deciduous teeth, premature exfoliation of fully rooted permanent teeth, severe dental caries and alveolar bone loss. This clinical report describes the prosthetic rehabilitation of a sixteen year old female patient with hypophosphatasia with partial anodontia and no occlusion. Patient was managed clinically by saving her remaining teeth, fabricating a maxillary overdenture and mandibular cast partial denture. This not only helped her functionally in biting and chewing food and achieving a good occlusion, but also restored her confidence and self image by improving the aesthetics.http://www.contempclindent.org/article.asp?issn=0976-237X;year=2012;volume=3;issue=1;spage=74;epage=77;aulast=GrewalAlkaline phosphatase levelsAlveolar bone atrophyanodontiacomplete rehabilitationhypophosphatasiaserum |
| spellingShingle | Partapjot S Grewal Kanu Priya Gupta Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report Contemporary Clinical Dentistry Alkaline phosphatase levels Alveolar bone atrophy anodontia complete rehabilitation hypophosphatasia serum |
| title | Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report |
| title_full | Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report |
| title_fullStr | Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report |
| title_full_unstemmed | Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report |
| title_short | Prosthetic rehabilitation of a young patient with Hypophosphatasia - A review and case report |
| title_sort | prosthetic rehabilitation of a young patient with hypophosphatasia a review and case report |
| topic | Alkaline phosphatase levels Alveolar bone atrophy anodontia complete rehabilitation hypophosphatasia serum |
| url | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2012;volume=3;issue=1;spage=74;epage=77;aulast=Grewal |
| work_keys_str_mv | AT partapjotsgrewal prostheticrehabilitationofayoungpatientwithhypophosphatasiaareviewandcasereport AT kanupriyagupta prostheticrehabilitationofayoungpatientwithhypophosphatasiaareviewandcasereport |