Early use of everolimus improved renal function after adult deceased donor liver transplantation
Background : Tacrolimus (TAC) is a main therapy for liver transplantation (LT) patients, but it has side effects such as chronic nephrotoxicity that progressively aggravate renal function. The purpose of this study was to retrospectively compare the renal function between a TAC group and a combinati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2021-03-01
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| Series: | Korean Journal of Transplantation |
| Subjects: | |
| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.20.0043 |
| _version_ | 1797334887634567168 |
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| author | Seohee Lee Jong Man Kim Sangjin Kim Jinsoo Rhu Gyu-Seong Choi Jae-Won Joh |
| author_facet | Seohee Lee Jong Man Kim Sangjin Kim Jinsoo Rhu Gyu-Seong Choi Jae-Won Joh |
| author_sort | Seohee Lee |
| collection | DOAJ |
| description | Background : Tacrolimus (TAC) is a main therapy for liver transplantation (LT) patients, but it has side effects such as chronic nephrotoxicity that progressively aggravate renal function. The purpose of this study was to retrospectively compare the renal function between a TAC group and a combination of everolimus and reduced TAC (EVR-TAC) group after deceased donor liver transplantation (DDLT). Methods : The study comprised 131 patients who underwent DDLT between January 2013 and April 2018 at our institution. They received TAC or EVR-TAC after DDLT. Everolimus (EVR) was introduced between 1 and 6 months after DDLT. Results : Thirty-six of 131 patients (27.5%) received EVR-TAC. The incidence of chronic kidney disease (CKD; estimated glomerular filtration rate, <60 mL/1.73 m2) in the EVRTAC group was higher than in the TAC group (25% vs. 8.4%; P=0.019). Increasing serum creatinine (n=23, 63.9%) was the most common cause for adding EVR to treatment of the posttransplant patients. There were no statistical differences in acute rejection and CKD between the two groups. The TAC trough level was significantly lower in the EVRTAC group than in the TAC group, and the renal function of the EVR-TAC group was worse than that of the TAC group until 1 year after DDLT. However, the renal function of the EVRTAC group improved and became similar to that of TAC group at 3 years posttransplant. Conclusions: The present study suggests that EVR should be introduced as soon as possible after DDLT to reduce exposure to high doses of TAC to improve the renal function. |
| first_indexed | 2024-03-08T08:27:44Z |
| format | Article |
| id | doaj.art-c2426bc627464689877f65713b72563c |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T08:27:44Z |
| publishDate | 2021-03-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-c2426bc627464689877f65713b72563c2024-02-02T04:20:12ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902021-03-0135181410.4285/kjt.20.0043kjt.20.0043Early use of everolimus improved renal function after adult deceased donor liver transplantationSeohee Lee0Jong Man Kim1Sangjin Kim2Jinsoo Rhu3Gyu-Seong Choi4Jae-Won Joh5Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground : Tacrolimus (TAC) is a main therapy for liver transplantation (LT) patients, but it has side effects such as chronic nephrotoxicity that progressively aggravate renal function. The purpose of this study was to retrospectively compare the renal function between a TAC group and a combination of everolimus and reduced TAC (EVR-TAC) group after deceased donor liver transplantation (DDLT). Methods : The study comprised 131 patients who underwent DDLT between January 2013 and April 2018 at our institution. They received TAC or EVR-TAC after DDLT. Everolimus (EVR) was introduced between 1 and 6 months after DDLT. Results : Thirty-six of 131 patients (27.5%) received EVR-TAC. The incidence of chronic kidney disease (CKD; estimated glomerular filtration rate, <60 mL/1.73 m2) in the EVRTAC group was higher than in the TAC group (25% vs. 8.4%; P=0.019). Increasing serum creatinine (n=23, 63.9%) was the most common cause for adding EVR to treatment of the posttransplant patients. There were no statistical differences in acute rejection and CKD between the two groups. The TAC trough level was significantly lower in the EVRTAC group than in the TAC group, and the renal function of the EVR-TAC group was worse than that of the TAC group until 1 year after DDLT. However, the renal function of the EVRTAC group improved and became similar to that of TAC group at 3 years posttransplant. Conclusions: The present study suggests that EVR should be introduced as soon as possible after DDLT to reduce exposure to high doses of TAC to improve the renal function.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.20.0043renal insufficiency; immunosuppression; calcineurin inhibitors |
| spellingShingle | Seohee Lee Jong Man Kim Sangjin Kim Jinsoo Rhu Gyu-Seong Choi Jae-Won Joh Early use of everolimus improved renal function after adult deceased donor liver transplantation Korean Journal of Transplantation renal insufficiency; immunosuppression; calcineurin inhibitors |
| title | Early use of everolimus improved renal function after adult deceased donor liver transplantation |
| title_full | Early use of everolimus improved renal function after adult deceased donor liver transplantation |
| title_fullStr | Early use of everolimus improved renal function after adult deceased donor liver transplantation |
| title_full_unstemmed | Early use of everolimus improved renal function after adult deceased donor liver transplantation |
| title_short | Early use of everolimus improved renal function after adult deceased donor liver transplantation |
| title_sort | early use of everolimus improved renal function after adult deceased donor liver transplantation |
| topic | renal insufficiency; immunosuppression; calcineurin inhibitors |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.20.0043 |
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