Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma
Introduction/Objective. Rib fractures are common in blunt chest trauma (BCT), and when they are associated with pleural complications (PC) – pneumothorax, hemothorax and hemopneumothorax – the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractur...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2023-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300073P.pdf |
| _version_ | 1797393693376774144 |
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| author | Pavlović Milorad Ristić Tatjana Marković Dušanka Ignjatović Aleksandra Karanikolić Aleksandar Đorđević Miodrag Radić Milica Dinić Ljubimir Laketić Darko |
| author_facet | Pavlović Milorad Ristić Tatjana Marković Dušanka Ignjatović Aleksandra Karanikolić Aleksandar Đorđević Miodrag Radić Milica Dinić Ljubimir Laketić Darko |
| author_sort | Pavlović Milorad |
| collection | DOAJ |
| description | Introduction/Objective. Rib fractures are common in blunt chest trauma (BCT), and when they are associated with pleural complications (PC) – pneumothorax, hemothorax and hemopneumothorax – the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractures in BCT, most doctors are forced to initially treat these patients through observation and conservative treatment. The goal of this research is to determine which of the investigated biomarkers of inflammation – fibrinogen, interleukin-6 (IL-6), and C-reactive protein (CRP) – are significantly associated with the occurrence of PC after rib fracture in BCT, and whether they can be used in stratifying patients for hospitalization and further treatment. Methods. The prospective study included 90 patients with rib fractures caused by BCT. The test group comprised 45 patients with rib fractures and the presence of PC, and the control group consisted of 45 patients with rib fractures without PC. Blood sampling was performed on admission, on the second, third, and fifth day after the injury, and PC were monitored until the seventh day after the injury. Results. Serum values of IL-6 on the second day and fibrinogen and CRP on the second and third day after injury were statistically significantly higher in patients with PC, and IL-6 showed a good discriminative ability in assessing the occurrence of PC on the second day after a rib fracture in BCT. Conclusion. The investigated biomarkers of inflammation – fibrinogen, IL-6, and CRP – can be used as predictors of PC after rib fracture in BCT, and their application can significantly replace clinical observation. |
| first_indexed | 2024-03-09T00:07:30Z |
| format | Article |
| id | doaj.art-c243c895120c41e3a5af8603e992571e |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-03-09T00:07:30Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-c243c895120c41e3a5af8603e992571e2023-12-12T13:09:04ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952023-01-011519-1055556010.2298/SARH221221073P0370-81792300073PSignificance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest traumaPavlović Milorad0Ristić Tatjana1Marković Dušanka2Ignjatović Aleksandra3https://orcid.org/0000-0002-2689-8088Karanikolić Aleksandar4Đorđević Miodrag5Radić Milica6Dinić Ljubimir7Laketić Darko8https://orcid.org/0000-0001-8228-8041Niš University Clinical Center, Clinic of Thoracic surgery, Niš, SerbiaNiš University Clinical Center, Center for Medical and Clinical Biochemistry, Niš, SerbiaNiš University Clinical Center, Center for Medical and Clinical Biochemistry, Immunology Diagnostics Department, Niš, SerbiaUniversity of Niš, Faculty of Medicine, Department of Medical Statistics and Informatics, Niš, SerbiaNiš University Clinical Center, Clinic of Endocrine Surgery, Niš, SerbiaNiš University Clinical Center, Clinic of Endocrine Surgery, Niš, SerbiaNiš University Clinical Center, Clinic of Oncology, Department for Radiotherapy, Niš, SerbiaNiš University Clinical Center, Clinic of Urology, Niš, SerbiaUniversity of Belgrade, Faculty of Medicine, Niko Miljanić Institute of Anatomy, Belgrade, SerbiaIntroduction/Objective. Rib fractures are common in blunt chest trauma (BCT), and when they are associated with pleural complications (PC) – pneumothorax, hemothorax and hemopneumothorax – the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractures in BCT, most doctors are forced to initially treat these patients through observation and conservative treatment. The goal of this research is to determine which of the investigated biomarkers of inflammation – fibrinogen, interleukin-6 (IL-6), and C-reactive protein (CRP) – are significantly associated with the occurrence of PC after rib fracture in BCT, and whether they can be used in stratifying patients for hospitalization and further treatment. Methods. The prospective study included 90 patients with rib fractures caused by BCT. The test group comprised 45 patients with rib fractures and the presence of PC, and the control group consisted of 45 patients with rib fractures without PC. Blood sampling was performed on admission, on the second, third, and fifth day after the injury, and PC were monitored until the seventh day after the injury. Results. Serum values of IL-6 on the second day and fibrinogen and CRP on the second and third day after injury were statistically significantly higher in patients with PC, and IL-6 showed a good discriminative ability in assessing the occurrence of PC on the second day after a rib fracture in BCT. Conclusion. The investigated biomarkers of inflammation – fibrinogen, IL-6, and CRP – can be used as predictors of PC after rib fracture in BCT, and their application can significantly replace clinical observation.https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300073P.pdfblunt chest traumarib fracturespleural complicationsfibrinogenil-6crp |
| spellingShingle | Pavlović Milorad Ristić Tatjana Marković Dušanka Ignjatović Aleksandra Karanikolić Aleksandar Đorđević Miodrag Radić Milica Dinić Ljubimir Laketić Darko Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma Srpski Arhiv za Celokupno Lekarstvo blunt chest trauma rib fractures pleural complications fibrinogen il-6 crp |
| title | Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| title_full | Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| title_fullStr | Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| title_full_unstemmed | Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| title_short | Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| title_sort | significance of fibrinogen interleukin 6 and c reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma |
| topic | blunt chest trauma rib fractures pleural complications fibrinogen il-6 crp |
| url | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300073P.pdf |
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