Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure
Fine particulate matter (PM2.5) has attracted more and more attention in the field of environmental pollution and public health. Previous studies have found that PM2.5 can be inhaled and deposit in the airway and alveoli, and even spread to the whole-body tissues and organs through blood, resulting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2022-06-01
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| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM21486 |
| _version_ | 1811225330953748480 |
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| author | Yuan JIANG Jinbo LIU Jianjun DENG |
| author_facet | Yuan JIANG Jinbo LIU Jianjun DENG |
| author_sort | Yuan JIANG |
| collection | DOAJ |
| description | Fine particulate matter (PM2.5) has attracted more and more attention in the field of environmental pollution and public health. Previous studies have found that PM2.5 can be inhaled and deposit in the airway and alveoli, and even spread to the whole-body tissues and organs through blood, resulting in various toxic effects. The malignant transformation of lung epithelial cells associated with long-term exposure to PM2.5 may play an important role in the occurrence and development of lung cancer. This paper reviewed recent studies on the mechanisms of malignant transformation of lung epithelial cells associated with PM2.5 exposure, and discussed the main biological mechanisms, including epigenetics, tumor microenvironment, and other biological pathways. Besides, the potential research directions of malignant transformation of lung epithelial cells associated with PM2.5 exposure were proposed. This work aims to provide a scientific basis and reference for public health management and air quality assessment. |
| first_indexed | 2024-04-12T09:04:09Z |
| format | Article |
| id | doaj.art-c2441e1e01ba4f3ea8dee886ac70ed1a |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-04-12T09:04:09Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-c2441e1e01ba4f3ea8dee886ac70ed1a2022-12-22T03:39:08ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822022-06-0139670871310.11836/JEOM2148621486Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposureYuan JIANG0Jinbo LIU1Jianjun DENG2Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaFine particulate matter (PM2.5) has attracted more and more attention in the field of environmental pollution and public health. Previous studies have found that PM2.5 can be inhaled and deposit in the airway and alveoli, and even spread to the whole-body tissues and organs through blood, resulting in various toxic effects. The malignant transformation of lung epithelial cells associated with long-term exposure to PM2.5 may play an important role in the occurrence and development of lung cancer. This paper reviewed recent studies on the mechanisms of malignant transformation of lung epithelial cells associated with PM2.5 exposure, and discussed the main biological mechanisms, including epigenetics, tumor microenvironment, and other biological pathways. Besides, the potential research directions of malignant transformation of lung epithelial cells associated with PM2.5 exposure were proposed. This work aims to provide a scientific basis and reference for public health management and air quality assessment.http://www.jeom.org/article/cn/10.11836/JEOM21486pm2.5lung epithelial cellmalignant transformationlung cancerepigeneticstumor microenvironment |
| spellingShingle | Yuan JIANG Jinbo LIU Jianjun DENG Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure 环境与职业医学 pm2.5 lung epithelial cell malignant transformation lung cancer epigenetics tumor microenvironment |
| title | Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure |
| title_full | Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure |
| title_fullStr | Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure |
| title_full_unstemmed | Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure |
| title_short | Research progress on mechanisms of malignant transformation of lung epithelial cells induced by PM2.5 exposure |
| title_sort | research progress on mechanisms of malignant transformation of lung epithelial cells induced by pm2 5 exposure |
| topic | pm2.5 lung epithelial cell malignant transformation lung cancer epigenetics tumor microenvironment |
| url | http://www.jeom.org/article/cn/10.11836/JEOM21486 |
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