Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium
The primary purpose of the current study was to study the possible pernicious effects of phosphine gas on enzyme activity alterations in Trogoderma granarium to determine its harmfulness to human beings after its prolonged exposure and intake. The saline extract of the adult Khapra beetle was bioche...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/15593258221095327 |
| _version_ | 1811324761473548288 |
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| author | Asma Naeem Asma Waheed Qureshi Shafia Arshad Anila Shehzadi Asim Kamran Shehla Noreen |
| author_facet | Asma Naeem Asma Waheed Qureshi Shafia Arshad Anila Shehzadi Asim Kamran Shehla Noreen |
| author_sort | Asma Naeem |
| collection | DOAJ |
| description | The primary purpose of the current study was to study the possible pernicious effects of phosphine gas on enzyme activity alterations in Trogoderma granarium to determine its harmfulness to human beings after its prolonged exposure and intake. The saline extract of the adult Khapra beetle was biochemically analyzed at different doses, that is, from 10ppm to 30ppm, to accurately evaluate the effects of various phosphine concentrations (LC 30 and LC 50 ) on 2 distinct strains of this insect pest gathered from different godowns of Pakistan as resistant (Chitral [Chi], Haroon Abad [Hbd], and Lahore [Lhr]) and susceptible (Faqeer wali [Fqw], Khanewal [Khw], and Rawalpindi [Rwp]) populations. Our experimental results suggest that the enzyme levels (AcP, AkP, ALAT, ASAT, LDH, and ICDH) seemed to be elevated with increasing dosage of phosphine from 10ppm to 30ppm in the resistant populace of the susceptible ones. It also illustrates that phosphine and its residues can inhibit the workability of certain enzymes that are vital for respiration and neuro reactions in hexapods and mammals. It has detrimental effects of phosphine on human health profile to consume stored food products containing such tenacious enemies. |
| first_indexed | 2024-04-13T14:20:09Z |
| format | Article |
| id | doaj.art-c244952740734f7f8a63122b57a65fc8 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-04-13T14:20:09Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-c244952740734f7f8a63122b57a65fc82022-12-22T02:43:30ZengSAGE PublishingDose-Response1559-32582022-05-012010.1177/15593258221095327Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granariumAsma NaeemAsma Waheed QureshiShafia ArshadAnila ShehzadiAsim KamranShehla NoreenThe primary purpose of the current study was to study the possible pernicious effects of phosphine gas on enzyme activity alterations in Trogoderma granarium to determine its harmfulness to human beings after its prolonged exposure and intake. The saline extract of the adult Khapra beetle was biochemically analyzed at different doses, that is, from 10ppm to 30ppm, to accurately evaluate the effects of various phosphine concentrations (LC 30 and LC 50 ) on 2 distinct strains of this insect pest gathered from different godowns of Pakistan as resistant (Chitral [Chi], Haroon Abad [Hbd], and Lahore [Lhr]) and susceptible (Faqeer wali [Fqw], Khanewal [Khw], and Rawalpindi [Rwp]) populations. Our experimental results suggest that the enzyme levels (AcP, AkP, ALAT, ASAT, LDH, and ICDH) seemed to be elevated with increasing dosage of phosphine from 10ppm to 30ppm in the resistant populace of the susceptible ones. It also illustrates that phosphine and its residues can inhibit the workability of certain enzymes that are vital for respiration and neuro reactions in hexapods and mammals. It has detrimental effects of phosphine on human health profile to consume stored food products containing such tenacious enemies.https://doi.org/10.1177/15593258221095327 |
| spellingShingle | Asma Naeem Asma Waheed Qureshi Shafia Arshad Anila Shehzadi Asim Kamran Shehla Noreen Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium Dose-Response |
| title | Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium |
| title_full | Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium |
| title_fullStr | Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium |
| title_full_unstemmed | Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium |
| title_short | Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium |
| title_sort | biochemical toxic response of phosphine on human health estimated from enzymatic variance in trogoderma granarium |
| url | https://doi.org/10.1177/15593258221095327 |
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