Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009.
An estimated 2.4 billion people live in areas at risk of dengue transmission, therefore the factors determining the establishment of endemic dengue in areas where transmission suitability is marginal is of considerable importance. Hanoi, Vietnam is such an area, and following a large dengue outbreak...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3181236?pdf=render |
| _version_ | 1811299173882920960 |
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| author | Hoang Quoc Cuong Nguyen Tran Hien Tran Nhu Duong Tran Vu Phong Nguyen Nhat Cam Jeremy Farrar Vu Sinh Nam Khoa T D Thai Peter Horby |
| author_facet | Hoang Quoc Cuong Nguyen Tran Hien Tran Nhu Duong Tran Vu Phong Nguyen Nhat Cam Jeremy Farrar Vu Sinh Nam Khoa T D Thai Peter Horby |
| author_sort | Hoang Quoc Cuong |
| collection | DOAJ |
| description | An estimated 2.4 billion people live in areas at risk of dengue transmission, therefore the factors determining the establishment of endemic dengue in areas where transmission suitability is marginal is of considerable importance. Hanoi, Vietnam is such an area, and following a large dengue outbreak in 2009, we set out to determine if dengue is emerging in Hanoi.We undertook a temporal and spatial analysis of 25,983 dengue cases notified in Hanoi between 1998 and 2009. Age standardized incidence rates, standardized age of infection, and Standardized Morbidity Ratios (SMR) were calculated. A quasi-Poisson regression model was used to determine if dengue incidence was increasing over time. Wavelet analysis was used to explore the periodicity of dengue transmission and the association with climate variables. After excluding the two major outbreak years of 1998 and 2009 and correcting for changes in population age structure, we identified a significant annual increase in the incidence of dengue cases over the period 1999-2008 (incidence rate ratio = 1.38, 95% confidence interval = 1.20-1.58, p value = 0.002). The age of notified dengue cases in Hanoi is high, with a median age of 23 years (mean 26.3 years). After adjusting for changes in population age structure, there was no statistically significant change in the median or mean age of dengue cases over the period studied. Districts in the central, highly urban, area of Hanoi have the highest incidence of dengue (SMR>3).Hanoi is a low dengue transmission setting where dengue incidence has been increasing year on year since 1999. This trend needs to be confirmed with serological surveys, followed by studies to determine the underlying drivers of this emergence. Such studies can provide insights into the biological, demographic, and environmental changes associated with vulnerability to the establishment of endemic dengue. |
| first_indexed | 2024-04-13T06:31:22Z |
| format | Article |
| id | doaj.art-c2452a0b8d7a4cd88efc9e1a02d01918 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T06:31:22Z |
| publishDate | 2011-09-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-c2452a0b8d7a4cd88efc9e1a02d019182022-12-22T02:58:08ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352011-09-0159e132210.1371/journal.pntd.0001322Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009.Hoang Quoc CuongNguyen Tran HienTran Nhu DuongTran Vu PhongNguyen Nhat CamJeremy FarrarVu Sinh NamKhoa T D ThaiPeter HorbyAn estimated 2.4 billion people live in areas at risk of dengue transmission, therefore the factors determining the establishment of endemic dengue in areas where transmission suitability is marginal is of considerable importance. Hanoi, Vietnam is such an area, and following a large dengue outbreak in 2009, we set out to determine if dengue is emerging in Hanoi.We undertook a temporal and spatial analysis of 25,983 dengue cases notified in Hanoi between 1998 and 2009. Age standardized incidence rates, standardized age of infection, and Standardized Morbidity Ratios (SMR) were calculated. A quasi-Poisson regression model was used to determine if dengue incidence was increasing over time. Wavelet analysis was used to explore the periodicity of dengue transmission and the association with climate variables. After excluding the two major outbreak years of 1998 and 2009 and correcting for changes in population age structure, we identified a significant annual increase in the incidence of dengue cases over the period 1999-2008 (incidence rate ratio = 1.38, 95% confidence interval = 1.20-1.58, p value = 0.002). The age of notified dengue cases in Hanoi is high, with a median age of 23 years (mean 26.3 years). After adjusting for changes in population age structure, there was no statistically significant change in the median or mean age of dengue cases over the period studied. Districts in the central, highly urban, area of Hanoi have the highest incidence of dengue (SMR>3).Hanoi is a low dengue transmission setting where dengue incidence has been increasing year on year since 1999. This trend needs to be confirmed with serological surveys, followed by studies to determine the underlying drivers of this emergence. Such studies can provide insights into the biological, demographic, and environmental changes associated with vulnerability to the establishment of endemic dengue.http://europepmc.org/articles/PMC3181236?pdf=render |
| spellingShingle | Hoang Quoc Cuong Nguyen Tran Hien Tran Nhu Duong Tran Vu Phong Nguyen Nhat Cam Jeremy Farrar Vu Sinh Nam Khoa T D Thai Peter Horby Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. PLoS Neglected Tropical Diseases |
| title | Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. |
| title_full | Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. |
| title_fullStr | Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. |
| title_full_unstemmed | Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. |
| title_short | Quantifying the emergence of dengue in Hanoi, Vietnam: 1998-2009. |
| title_sort | quantifying the emergence of dengue in hanoi vietnam 1998 2009 |
| url | http://europepmc.org/articles/PMC3181236?pdf=render |
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