Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation
Abstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed D...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-93384-5 |
| _version_ | 1831520089806995456 |
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| author | Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon |
| author_facet | Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon |
| author_sort | Sung Uk Baek |
| collection | DOAJ |
| description | Abstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed DR patients who had completed PRP in at least one eye with a 3-year follow-up. A total of 243 eyes of 243 subjects (mean age 52.6 ± 11.6 years) were enrolled. Among them, 52 patients (21.4%) showed progression of DR after PRP (progression group), and the other 191 (78.6%) patients had stable DR (non-progression group). The progression group had higher proportion of proliferative DR (P = 0.019); lower baseline visual acuity (P < 0.001); and higher platelet count (P = 0.048), hemoglobin (P = 0.044), and hematocrit, (P = 0.042) than the non-progression group. In the multivariate logistic regression analysis for progression of DR, baseline visual acuity (HR: 0.053, P < 0.001) and platelet count (HR: 1.215, P = 0.031) were identified as risk factors for progression. Consequently, we propose that patients with low visual acuity or high platelet count are more likely to have progressive DR despite PRP and require careful observation. Also, the evaluation of hemorheological factors including platelet counts before PRP can be considered useful in predicting the prognosis of DR. |
| first_indexed | 2024-12-13T17:27:12Z |
| format | Article |
| id | doaj.art-c2474812c6764b4280d5bc122f5ffe87 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:27:12Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c2474812c6764b4280d5bc122f5ffe872022-12-21T23:37:10ZengNature PortfolioScientific Reports2045-23222021-07-0111111010.1038/s41598-021-93384-5Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulationSung Uk Baek0Min Seon Park1Bum-Joo Cho2In Won Park3Soonil Kwon4Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University College of MedicineAbstract Uncontrolled diabetes has been associated with progression of diabetic retinopathy (DR) in several studies. Therefore, we aimed to investigate systemic and ophthalmic factors related to worsening of DR even after completion of panretinal photocoagulation (PRP). We retrospectively reviewed DR patients who had completed PRP in at least one eye with a 3-year follow-up. A total of 243 eyes of 243 subjects (mean age 52.6 ± 11.6 years) were enrolled. Among them, 52 patients (21.4%) showed progression of DR after PRP (progression group), and the other 191 (78.6%) patients had stable DR (non-progression group). The progression group had higher proportion of proliferative DR (P = 0.019); lower baseline visual acuity (P < 0.001); and higher platelet count (P = 0.048), hemoglobin (P = 0.044), and hematocrit, (P = 0.042) than the non-progression group. In the multivariate logistic regression analysis for progression of DR, baseline visual acuity (HR: 0.053, P < 0.001) and platelet count (HR: 1.215, P = 0.031) were identified as risk factors for progression. Consequently, we propose that patients with low visual acuity or high platelet count are more likely to have progressive DR despite PRP and require careful observation. Also, the evaluation of hemorheological factors including platelet counts before PRP can be considered useful in predicting the prognosis of DR.https://doi.org/10.1038/s41598-021-93384-5 |
| spellingShingle | Sung Uk Baek Min Seon Park Bum-Joo Cho In Won Park Soonil Kwon Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation Scientific Reports |
| title | Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| title_full | Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| title_fullStr | Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| title_full_unstemmed | Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| title_short | Risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| title_sort | risk factors associated with progression of diabetic retinopathy in eyes treated with panretinal photocoagulation |
| url | https://doi.org/10.1038/s41598-021-93384-5 |
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