FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c

FOXM1b, which is present at elevated levels in cancer cells, has a greater transforming potential than FOXM1c

The Forkhead box (FOX) M1 transcription factor is required to maintain the proliferation of cancer cells. Two transcriptionally active isoforms of FOXM1, FOXM1b and FOXM1c, have been identified, but their functional differences remain unclear. FOXM1c is distinguished from FOXM1b by an extra exon (ex...

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Bibliographic Details
Main Authors: Andy King Yin Lam, Adaline Wan Ling Ngan, Man-Hong eLeung, Davis C T Kwok, Vincent Wing Sun Liu, David W Chan, Wai Ying eLeung, Kwok-Ming eYao
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Oncology
Subjects:
FOXM1b
FOXM1c
transforming potential
MEK1
proteolytic processing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00011/full

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