Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors

Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors

Abstract Background The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule cell precursors (GCPs) in the externa...

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Bibliographic Details
Main Authors: Alexandre Wojcinski, Morgane Morabito, Andrew K. Lawton, Daniel N. Stephen, Alexandra L. Joyner
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Neural Development
Subjects:
Cerebellum
SHH signaling
GLI2
Nestin-expressing progenitors
Neurogenesis
Atoh1-Cre
Online Access:http://link.springer.com/article/10.1186/s13064-019-0128-y

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