Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain?
Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16),...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1329057/full |
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| author | Jakub Makarewicz Karolina Kaźmierczak-Siedlecka Bartosz Kamil Sobocki Iwona T. Dobrucki Iwona T. Dobrucki Iwona T. Dobrucki Leszek Kalinowski Leszek Kalinowski Ewa Stachowska |
| author_facet | Jakub Makarewicz Karolina Kaźmierczak-Siedlecka Bartosz Kamil Sobocki Iwona T. Dobrucki Iwona T. Dobrucki Iwona T. Dobrucki Leszek Kalinowski Leszek Kalinowski Ewa Stachowska |
| author_sort | Jakub Makarewicz |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein–Barr virus, tobacco, alcohol, and poor oral hygiene with approximately 4.5% of global cancers linked to HPV. Notably, differences in the microbiome between healthy individuals and patients with head and neck cancers (HNCs) have been identified. Recent studies highlight the significance of certain oral microbes in risk assessment and the potential of the microbiome as a biomarker for HNCs. Additionally, role of the microbiome in metastasis has been acknowledged. Treatment for HNCs includes local methods, such as surgery and radiotherapy, and systemic approaches, such as immunotherapy. Numerous side effects accompany these treatments. Emerging research suggests the beneficial role of preoperative immunonutrition and probiotics in patient outcomes, emphasizing the influence of the microbiome on treatment efficacy. This review explores the reciprocal effects of HNC treatment and the gut microbiome using radiotherapy, brachytherapy, surgery, immunotherapy, and chemotherapy. |
| first_indexed | 2024-03-07T20:06:23Z |
| format | Article |
| id | doaj.art-c24a59ee26664aabb0a5b80df5a3f9b2 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-07T20:06:23Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-c24a59ee26664aabb0a5b80df5a3f9b22024-02-28T05:10:04ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-02-011410.3389/fcimb.2024.13290571329057Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain?Jakub Makarewicz0Karolina Kaźmierczak-Siedlecka1Bartosz Kamil Sobocki2Iwona T. Dobrucki3Iwona T. Dobrucki4Iwona T. Dobrucki5Leszek Kalinowski6Leszek Kalinowski7Ewa Stachowska8Scientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, PolandDepartment of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, PolandDepartment of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, PolandDepartment of Bioengineering, University of Illinois at Urbana—Champaign, Urbana, IL, United StatesBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana—Champaign, Urbana, IL, United StatesDepartment of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois at Urbana—Champaign, Urbana, IL, United StatesDepartment of Medical Laboratory Diagnostics—Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, PolandBioTechMed Centre, Department of Mechanics of Materials and Structures, Gdansk University of Technology, Gdansk, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Szczecin, PolandHead and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein–Barr virus, tobacco, alcohol, and poor oral hygiene with approximately 4.5% of global cancers linked to HPV. Notably, differences in the microbiome between healthy individuals and patients with head and neck cancers (HNCs) have been identified. Recent studies highlight the significance of certain oral microbes in risk assessment and the potential of the microbiome as a biomarker for HNCs. Additionally, role of the microbiome in metastasis has been acknowledged. Treatment for HNCs includes local methods, such as surgery and radiotherapy, and systemic approaches, such as immunotherapy. Numerous side effects accompany these treatments. Emerging research suggests the beneficial role of preoperative immunonutrition and probiotics in patient outcomes, emphasizing the influence of the microbiome on treatment efficacy. This review explores the reciprocal effects of HNC treatment and the gut microbiome using radiotherapy, brachytherapy, surgery, immunotherapy, and chemotherapy.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1329057/fullhead and neck cancersoral mucositisradiotherapybrachytherapychemotherapymicrobiome |
| spellingShingle | Jakub Makarewicz Karolina Kaźmierczak-Siedlecka Bartosz Kamil Sobocki Iwona T. Dobrucki Iwona T. Dobrucki Iwona T. Dobrucki Leszek Kalinowski Leszek Kalinowski Ewa Stachowska Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? Frontiers in Cellular and Infection Microbiology head and neck cancers oral mucositis radiotherapy brachytherapy chemotherapy microbiome |
| title | Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? |
| title_full | Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? |
| title_fullStr | Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? |
| title_full_unstemmed | Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? |
| title_short | Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain? |
| title_sort | anti cancer management of head and neck cancers and oral microbiome what can we clinically obtain |
| topic | head and neck cancers oral mucositis radiotherapy brachytherapy chemotherapy microbiome |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1329057/full |
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