Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management
Abstract Background Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patient's characteristics. Biomarkers are crucial for identifying the patients who are expected to derive greatest advantage from targeted therapy. Main body...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-023-00573-2 |
| _version_ | 1827388699591049216 |
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| author | Dipak D. Gadade Hariom Jha Chetan Kumar Farzan Khan |
| author_facet | Dipak D. Gadade Hariom Jha Chetan Kumar Farzan Khan |
| author_sort | Dipak D. Gadade |
| collection | DOAJ |
| description | Abstract Background Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patient's characteristics. Biomarkers are crucial for identifying the patients who are expected to derive greatest advantage from targeted therapy. Main body Here, various biomarkers, including genetic, epigenetic, protein, and metabolites, and their clinical significance, are discussed. The review provides insights into the use of biomarkers and their clinical significance in cancer treatment. There are several hurdles in use of PM in oncology, such as the complexity of tumor biology and heterogeneity, limited availability of biomarkers, high cost of targeted therapies, resistance to targeted therapies, and ethical and social issues. Conclusion The biomarkers play a crucial diagnostic role in the treatment of cancer. The review also acknowledges the challenges and limitations of personalized medicine which, if resolved, can be helpful in the management of cancer. |
| first_indexed | 2024-03-08T16:22:41Z |
| format | Article |
| id | doaj.art-c24bfe67d7524d93a6e439028eda9e11 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-03-08T16:22:41Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-c24bfe67d7524d93a6e439028eda9e112024-01-07T12:14:51ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532024-01-0110111510.1186/s43094-023-00573-2Unlocking the power of precision medicine: exploring the role of biomarkers in cancer managementDipak D. Gadade0Hariom Jha1Chetan Kumar2Farzan Khan3Department of Pharmacy, DSEU Dwarka Campus (Formerly Integrated Institute of Technology), Delhi Skill and Entrepreneurship University, Government of NCT DelhiDepartment of Pharmacy, DSEU Dwarka Campus (Formerly Integrated Institute of Technology), Delhi Skill and Entrepreneurship University, Government of NCT DelhiDepartment of Pharmacy, DSEU Dwarka Campus (Formerly Integrated Institute of Technology), Delhi Skill and Entrepreneurship University, Government of NCT DelhiDepartment of Pharmacy, DSEU Dwarka Campus (Formerly Integrated Institute of Technology), Delhi Skill and Entrepreneurship University, Government of NCT DelhiAbstract Background Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patient's characteristics. Biomarkers are crucial for identifying the patients who are expected to derive greatest advantage from targeted therapy. Main body Here, various biomarkers, including genetic, epigenetic, protein, and metabolites, and their clinical significance, are discussed. The review provides insights into the use of biomarkers and their clinical significance in cancer treatment. There are several hurdles in use of PM in oncology, such as the complexity of tumor biology and heterogeneity, limited availability of biomarkers, high cost of targeted therapies, resistance to targeted therapies, and ethical and social issues. Conclusion The biomarkers play a crucial diagnostic role in the treatment of cancer. The review also acknowledges the challenges and limitations of personalized medicine which, if resolved, can be helpful in the management of cancer.https://doi.org/10.1186/s43094-023-00573-2Personalized medicineBiomarkersCancersGeneticsOncogenes |
| spellingShingle | Dipak D. Gadade Hariom Jha Chetan Kumar Farzan Khan Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management Future Journal of Pharmaceutical Sciences Personalized medicine Biomarkers Cancers Genetics Oncogenes |
| title | Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management |
| title_full | Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management |
| title_fullStr | Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management |
| title_full_unstemmed | Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management |
| title_short | Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management |
| title_sort | unlocking the power of precision medicine exploring the role of biomarkers in cancer management |
| topic | Personalized medicine Biomarkers Cancers Genetics Oncogenes |
| url | https://doi.org/10.1186/s43094-023-00573-2 |
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