Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery.

Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery.

Exosomes are small, cell-secreted vesicles that transfer proteins and genetic information between cells. This intercellular transmission regulates many physiological and pathological processes. Therefore, exosomes have emerged as novel biomarkers for disease diagnosis and as nanocarriers for drug de...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Ming Wang, Sarah Altinoglu, Yuji S Takeda, Qiaobing Xu
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Public Library of Science (PLoS) 2015-01-01
Cyfres:	PLoS ONE
Mynediad Ar-lein:	http://europepmc.org/articles/PMC4631329?pdf=render

Eitemau Tebyg

Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells
gan: Tianwei Huang, et al.
Cyhoeddwyd: (2023-03-01)

Bioorthogonal 4 H -pyrazole “click” reagents
gan: Abularrage, Nile S, et al.
Cyhoeddwyd: (2023)

Bioorthogonal “Click” Cycloadditions: A Toolkit for Modulating Polymers and Nanostructures in Living Systems
gan: Irene Lepori, et al.
Cyhoeddwyd: (2024-03-01)

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
gan: Xiu Zhang, et al.
Cyhoeddwyd: (2013-06-01)

Quantitative analysis of electroporation-mediated intracellular delivery via bioorthogonal luminescent reaction
gan: Shiqi Wang, et al.
Cyhoeddwyd: (2024-08-01)

Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals
gan: Sajid Mushtaq, et al.
Cyhoeddwyd: (2019-10-01)

Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery
gan: Ziyang Cao, et al.
Cyhoeddwyd: (2022-04-01)

Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging, drug targeting and delivery
gan: Jing Chen, et al.
Cyhoeddwyd: (2023-06-01)

User-friendly bioorthogonal reactions click to explore glycan functions in complex biological systems
gan: Xi Chen, et al.
Cyhoeddwyd: (2023-03-01)

Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction
gan: Bai Li, et al.
Cyhoeddwyd: (2019-07-01)

Extracellular Vesicles as Novel Drug-Delivery Systems through Intracellular Communications
gan: Yasunari Matsuzaka, et al.
Cyhoeddwyd: (2022-05-01)

Functional delivery of lipid-conjugated siRNA by extracellular vesicles
gan: O'Loughlin, A, et al.
Cyhoeddwyd: (2017)

Machine Learning‐Guided Computational Screening of New Candidate Reactions with High Bioorthogonal Click Potential
gan: Stuyver, Thijs, et al.
Cyhoeddwyd: (2025)

Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions
gan: Nathan Lagneau, et al.
Cyhoeddwyd: (2023-06-01)

Bioorthogonal Labeling and Chemoselective Functionalization of Lung Extracellular Matrix
gan: Zihan Ling, et al.
Cyhoeddwyd: (2021-02-01)

Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
gan: Yayue Wang, et al.
Cyhoeddwyd: (2020-11-01)

Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling
gan: Jingyi Zhao, et al.
Cyhoeddwyd: (2018-12-01)

Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry.
gan: Catherine Su Hui Teo, et al.
Cyhoeddwyd: (2016-10-01)

A Special Virtual Issue Celebrating the 2022 Nobel Prize in Chemistry for the Development of Click Chemistry and Bioorthogonal Chemistry
gan: Carolyn Bertozzi
Cyhoeddwyd: (2022-12-01)

Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry
gan: Alison Keolani Carlisle, et al.
Cyhoeddwyd: (2023-09-01)

Engineered Extracellular Vesicles for Drug Delivery in Therapy of Stroke
gan: Waqas Ahmed, et al.
Cyhoeddwyd: (2023-08-01)

Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications
gan: Liwei Wang, et al.
Cyhoeddwyd: (2023-06-01)

Click Chemistry with Cell-Permeable Fluorophores Expands the Choice of Bioorthogonal Markers for Two-Color Live-Cell STED Nanoscopy
gan: Carola Gregor, et al.
Cyhoeddwyd: (2024-04-01)

Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry
gan: Shima Tavakoli, et al.
Cyhoeddwyd: (2023-10-01)

Bioorthogonal CRISPR/Cas9‐Drug Conjugate: A Combinatorial Nanomedicine Platform
gan: Marcel Janis Beha, et al.
Cyhoeddwyd: (2023-09-01)

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries
gan: Ruan, Huitong, et al.
Cyhoeddwyd: (2023)

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries
gan: Huitong Ruan, et al.
Cyhoeddwyd: (2023-05-01)

CRISPR-Cas9 delivery strategies with engineered extracellular vesicles
gan: Yaoyao Lu, et al.
Cyhoeddwyd: (2023-12-01)

A Smart Intracellular Self‐Assembling Bioorthogonal Raman Active Nanoprobe for Targeted Tumor Imaging
gan: Swati Tanwar, et al.
Cyhoeddwyd: (2023-12-01)

Coupling Bioorthogonal Chemistries with Artificial Metabolism: Intracellular Biosynthesis of Azidohomoalanine and Its Incorporation into Recombinant Proteins
gan: Ying Ma, et al.
Cyhoeddwyd: (2014-01-01)

Bioorthogonal Diels–Alder Click Chemistry-Based Pretargeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression
gan: Yong Huang, et al.
Cyhoeddwyd: (2024-08-01)

Intracellular vesicles: Novel nanovesicles superior to extracellular vesicles in translational medicine and clinical applications
gan: Qingsong Ye, PhD, DDS, et al.
Cyhoeddwyd: (2024-12-01)

Characterizing Extracellular Vesicles Generated from the Integra CELLine Culture System and Their Endocytic Pathways for Intracellular Drug Delivery
gan: Tianjiao Geng, et al.
Cyhoeddwyd: (2024-09-01)

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery
gan: Ikuhiko Nakase, et al.
Cyhoeddwyd: (2017-05-01)

Small Extracellular Vesicles Engineered Using Click Chemistry to Express Chimeric Antigen Receptors Show Enhanced Efficacy in Acute Liver Failure
gan: Yen‐Ting Lu, et al.
Cyhoeddwyd: (2025-02-01)

Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy
gan: Chun-Jie Bao, et al.
Cyhoeddwyd: (2023-08-01)

Cationized extracellular vesicles for gene delivery
gan: Natalia L. Klyachko, et al.
Cyhoeddwyd: (2024-10-01)

Extracellular Vesicles: Delivery Vehicles of Myokines
gan: Eleonora Trovato, et al.
Cyhoeddwyd: (2019-05-01)

Design and synthesis of multivalent neoglycoconjugates by click conjugations
gan: Ding, Feiqing, et al.
Cyhoeddwyd: (2014)

Oligonucleotide Tagging for Copper-Free Click Conjugation
gan: Alan Rowan, et al.
Cyhoeddwyd: (2013-06-01)