Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

Avermectins, a group of polyketide natural products, are widely used as anthelmintics in agriculture. Metabolic engineering and combinatorial biosynthesis were extensively employed to improve Avermectins production and create novel Avermectin derivatives, including Ivermectin and Doramectin. It is l...

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Bibliographic Details
Main Authors: Qian Deng, Li Zhou, Meizhong Luo, Zixin Deng, Changming Zhao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Streptomyces
Avermectin
BAC library
Heterologous expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X17300364

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