PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL
<p><strong>Aim</strong> – to study how anthracyclines influence on cardiovascular system in patients with lymphomas and whether angiotensin-converting enzyme inhibitor Perindopril is cardioprotective in these patients.</p><p><br /><strong>Subjects and method...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Klinicist |
| Subjects: | |
| Online Access: | http://klinitsist.abvpress.ru/index.php/Klin/article/view/102 |
| _version_ | 1828077644118228992 |
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| author | E. V. Pravdivtseva N. G. Poteshkina A. M. Svanadze D. S. Rilskiy |
| author_facet | E. V. Pravdivtseva N. G. Poteshkina A. M. Svanadze D. S. Rilskiy |
| author_sort | E. V. Pravdivtseva |
| collection | DOAJ |
| description | <p><strong>Aim</strong> – to study how anthracyclines influence on cardiovascular system in patients with lymphomas and whether angiotensin-converting enzyme inhibitor Perindopril is cardioprotective in these patients.</p><p><br /><strong>Subjects and methods</strong>. 26 patients with Hodgkin’s disease and non-Hodgkin’s lymphomas were followed before and after treatment with<br />doxorubicin. 12 of these patients with arterial hypertension received angiotensin-converting enzyme inhibitor Рerindopril, 10 mg/d, during<br />treatment with doxorubicin. Cardiological evaluation was performed before and the next day after chemotherapy. Average dose of Doxorubicin was 34,99 ± 13,23 mg/m2.</p><p><br /><strong>Results.</strong> In patients receiving anthracyclines deceleration time DT increased significantly, a significant reduction in heart rate (HR), cardiac<br />output (CO) and cardiac index (CI) were observed also (рDT = 0,037, pHR = 0,048, рСО = 0,007, рCI = 0,007). In patients simultaneously<br />treated with Perindopril these parameters were not statistically different (рDT = 0,92, pHR = 0,22, рCO = 0,35, рCI = 0,39).</p><p><br /><strong>Conclusion.</strong> Administration of anthracyclines (average dose of Doxorubicin 34,99 ± 13,23 mg/m2) leads to DT of the left ventricle and<br />reduction in HR, CJ and CI. Simultaneous treatment with Perindopril in patients receiving anthracyclines preserves DF and prevents heart hemodynamics abnormalities.</p> |
| first_indexed | 2024-04-11T02:33:50Z |
| format | Article |
| id | doaj.art-c24d37c3533347faa20e90b4e0febeec |
| institution | Directory Open Access Journal |
| issn | 1818-8338 |
| language | Russian |
| last_indexed | 2024-04-11T02:33:50Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj.art-c24d37c3533347faa20e90b4e0febeec2023-01-02T20:44:07ZrusABV-pressKlinicist1818-83382014-07-01535560117PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRILE. V. Pravdivtseva0N. G. Poteshkina1A. M. Svanadze2D. S. Rilskiy3The Russian National Research Medical University named after N.I.PirogovThe Russian National Research Medical University named after N.I.PirogovThe Russian National Research Medical University named after N.I.PirogovThe Russian National Research Medical University named after N.I.Pirogov<p><strong>Aim</strong> – to study how anthracyclines influence on cardiovascular system in patients with lymphomas and whether angiotensin-converting enzyme inhibitor Perindopril is cardioprotective in these patients.</p><p><br /><strong>Subjects and methods</strong>. 26 patients with Hodgkin’s disease and non-Hodgkin’s lymphomas were followed before and after treatment with<br />doxorubicin. 12 of these patients with arterial hypertension received angiotensin-converting enzyme inhibitor Рerindopril, 10 mg/d, during<br />treatment with doxorubicin. Cardiological evaluation was performed before and the next day after chemotherapy. Average dose of Doxorubicin was 34,99 ± 13,23 mg/m2.</p><p><br /><strong>Results.</strong> In patients receiving anthracyclines deceleration time DT increased significantly, a significant reduction in heart rate (HR), cardiac<br />output (CO) and cardiac index (CI) were observed also (рDT = 0,037, pHR = 0,048, рСО = 0,007, рCI = 0,007). In patients simultaneously<br />treated with Perindopril these parameters were not statistically different (рDT = 0,92, pHR = 0,22, рCO = 0,35, рCI = 0,39).</p><p><br /><strong>Conclusion.</strong> Administration of anthracyclines (average dose of Doxorubicin 34,99 ± 13,23 mg/m2) leads to DT of the left ventricle and<br />reduction in HR, CJ and CI. Simultaneous treatment with Perindopril in patients receiving anthracyclines preserves DF and prevents heart hemodynamics abnormalities.</p>http://klinitsist.abvpress.ru/index.php/Klin/article/view/102angiotensin-converting enzyme inhibitorantracyclin cardiotoxicitydiastolic disfunctionchemotherapy |
| spellingShingle | E. V. Pravdivtseva N. G. Poteshkina A. M. Svanadze D. S. Rilskiy PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL Klinicist angiotensin-converting enzyme inhibitor antracyclin cardiotoxicity diastolic disfunction chemotherapy |
| title | PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL |
| title_full | PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL |
| title_fullStr | PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL |
| title_full_unstemmed | PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL |
| title_short | PREVENTION OF ANTRACYCLIN ANTIBIOTIC DOXORUBICIN СARDIOTOXICITY: A ROLE OF ACE-INHIBITOR PERINDOPRIL |
| title_sort | prevention of antracyclin antibiotic doxorubicin сardiotoxicity a role of ace inhibitor perindopril |
| topic | angiotensin-converting enzyme inhibitor antracyclin cardiotoxicity diastolic disfunction chemotherapy |
| url | http://klinitsist.abvpress.ru/index.php/Klin/article/view/102 |
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