Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy
Abstract A significant number of nucleic acid therapies have been approved, highlighting the vast potential of nucleic acid therapeutics. Although numerous delivery strategies have been investigated, and progress has been made in nucleic acid delivery systems, the oral delivery route still presents...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-04-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20230029 |
| _version_ | 1797200614138052608 |
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| author | Tingle Feng Waqas Ahmed Talha Ahmed Lukui Chen |
| author_facet | Tingle Feng Waqas Ahmed Talha Ahmed Lukui Chen |
| author_sort | Tingle Feng |
| collection | DOAJ |
| description | Abstract A significant number of nucleic acid therapies have been approved, highlighting the vast potential of nucleic acid therapeutics. Although numerous delivery strategies have been investigated, and progress has been made in nucleic acid delivery systems, the oral delivery route still presents a significant obstacle. Recently, a novel and promising force in oral nucleic acid delivery has emerged, namely Decoctosomes and Bencaosomes, obtained from the decoction of natural herbs, which refers to boiled Chinese herbal medicines. The active components of Decoctosomes include small molecules, peptides, and small RNAs (sRNAs). sRNAs were the first targets of extensive research. Additionally, Bencaosomes have been proven effective in several disease mouse models as artificially enhanced decoctosome products. This perspective summarizes the development and possible future directions of Decoctosomes and Bencaosomes, two varieties of nanoparticles that may open the door to new possibilities in nucleic acid therapy. |
| first_indexed | 2024-04-24T07:34:27Z |
| format | Article |
| id | doaj.art-c24d5bf80cab482fbcf926a60df5201e |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-04-24T07:34:27Z |
| publishDate | 2024-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-c24d5bf80cab482fbcf926a60df5201e2024-04-20T10:27:31ZengWiley-VCHInterdisciplinary Medicine2832-62452024-04-0122n/an/a10.1002/INMD.20230029Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapyTingle Feng0Waqas Ahmed1Talha Ahmed2Lukui Chen3Department of Neurosurgery Neuroscience Center Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong ChinaSchool of Medicine Southeast University Nanjing Jiangsu ChinaNowshera Medical College Nowshera PakistanDepartment of Neurosurgery Neuroscience Center Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong ChinaAbstract A significant number of nucleic acid therapies have been approved, highlighting the vast potential of nucleic acid therapeutics. Although numerous delivery strategies have been investigated, and progress has been made in nucleic acid delivery systems, the oral delivery route still presents a significant obstacle. Recently, a novel and promising force in oral nucleic acid delivery has emerged, namely Decoctosomes and Bencaosomes, obtained from the decoction of natural herbs, which refers to boiled Chinese herbal medicines. The active components of Decoctosomes include small molecules, peptides, and small RNAs (sRNAs). sRNAs were the first targets of extensive research. Additionally, Bencaosomes have been proven effective in several disease mouse models as artificially enhanced decoctosome products. This perspective summarizes the development and possible future directions of Decoctosomes and Bencaosomes, two varieties of nanoparticles that may open the door to new possibilities in nucleic acid therapy.https://doi.org/10.1002/INMD.20230029bencaosomedecoctosomenanoparticlenucleic acid delivery systemnucleic acid therapy |
| spellingShingle | Tingle Feng Waqas Ahmed Talha Ahmed Lukui Chen Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy Interdisciplinary Medicine bencaosome decoctosome nanoparticle nucleic acid delivery system nucleic acid therapy |
| title | Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy |
| title_full | Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy |
| title_fullStr | Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy |
| title_full_unstemmed | Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy |
| title_short | Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy |
| title_sort | nanoparticles derived from herbal preparations may represent a novel nucleic acid therapy |
| topic | bencaosome decoctosome nanoparticle nucleic acid delivery system nucleic acid therapy |
| url | https://doi.org/10.1002/INMD.20230029 |
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