The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series
Introduction: Cavernositis is a rare acute infection of the corporal bodies of the penis. It might result in corporal cavernosal abscesses, fibrosis, and subsequently erectile dysfunction if the treatment is inadequate. Previous reports advocate penile aspiration when cavernosal abscesses were signi...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-06-01
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| Series: | Sexual Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2050116120300362 |
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| author | Abdulaziz Bakhsh, MD, MBA Tareef Daqqaq, MD Ayman Alhasan, MD Mansour Alnazari, MD Emad Rajih, MD, MPH |
| author_facet | Abdulaziz Bakhsh, MD, MBA Tareef Daqqaq, MD Ayman Alhasan, MD Mansour Alnazari, MD Emad Rajih, MD, MPH |
| author_sort | Abdulaziz Bakhsh, MD, MBA |
| collection | DOAJ |
| description | Introduction: Cavernositis is a rare acute infection of the corporal bodies of the penis. It might result in corporal cavernosal abscesses, fibrosis, and subsequently erectile dysfunction if the treatment is inadequate. Previous reports advocate penile aspiration when cavernosal abscesses were significantly present. Aim: We report 2 cases of cavernositis treated by the standard antimicrobial therapy in addition to the daily use of phosphodiesterase type 5 inhibitors (iPDE-5). Methods: We include 2 patients who fulfill the criteria for the diagnosis of cavernositis. They were diagnosed clinically based on history and physical examination. Patient 1 had multifocal abscesses on initial penile contrast-enhanced magnetic resonance imaging (MRI). This patient showed rapid clinical improvement with the addition of phosphodiesterase inhibitor (PDEi) to the antimicrobial therapy without the need for surgical drainage of the abscesses. Patient 2 had persistent infection despite 3 weeks of oral second-generation cephalosporin (Cefuroxime). But he showed significant clinical improvement after being started on PDEi in conjunction with the current antimicrobial therapy. Follow-up after 3 months by clinical examination and penile magnetic resonance imaging in both patients showed normal erectile function with no scarring. Conclusion: PDEi have promising results on disease progression and outcomes. It synergizes the effect of antimicrobial therapy and can potentially reduce the residual corporal fibrosis and erectile dysfunction. However, large studies are required to validate and generalize this treatment approach.Bakhsh A, Daqqaq T, Alhasan A, et al. The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series. Sex Med 2020;8:318–322. |
| first_indexed | 2024-03-12T10:31:05Z |
| format | Article |
| id | doaj.art-c2501ff7eb7a452e899bc117951cbf7d |
| institution | Directory Open Access Journal |
| issn | 2050-1161 |
| language | English |
| last_indexed | 2024-03-12T10:31:05Z |
| publishDate | 2020-06-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Sexual Medicine |
| spelling | doaj.art-c2501ff7eb7a452e899bc117951cbf7d2023-09-02T09:15:50ZengOxford University PressSexual Medicine2050-11612020-06-0182318322The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case SeriesAbdulaziz Bakhsh, MD, MBA0Tareef Daqqaq, MD1Ayman Alhasan, MD2Mansour Alnazari, MD3Emad Rajih, MD, MPH4Department of Urology, Faculty of Medicine, Taibah University, Madinah, Saudi ArabiaDepartment of Radiology and Medical Imaging, Faculty of Medicine, Taibah University, Madinah, Saudi ArabiaDepartment of Radiology and Medical Imaging, Faculty of Medicine, Taibah University, Madinah, Saudi ArabiaDepartment of Urology, Faculty of Medicine, Taibah University, Madinah, Saudi ArabiaDepartment of Urology, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia; Corresponding Author: Emad Rajih, MD, MPH, Sexual Medicine & Minimal Invasive Urologic Surgery, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia. Tel: +966504350885; Fax: +966148440868Introduction: Cavernositis is a rare acute infection of the corporal bodies of the penis. It might result in corporal cavernosal abscesses, fibrosis, and subsequently erectile dysfunction if the treatment is inadequate. Previous reports advocate penile aspiration when cavernosal abscesses were significantly present. Aim: We report 2 cases of cavernositis treated by the standard antimicrobial therapy in addition to the daily use of phosphodiesterase type 5 inhibitors (iPDE-5). Methods: We include 2 patients who fulfill the criteria for the diagnosis of cavernositis. They were diagnosed clinically based on history and physical examination. Patient 1 had multifocal abscesses on initial penile contrast-enhanced magnetic resonance imaging (MRI). This patient showed rapid clinical improvement with the addition of phosphodiesterase inhibitor (PDEi) to the antimicrobial therapy without the need for surgical drainage of the abscesses. Patient 2 had persistent infection despite 3 weeks of oral second-generation cephalosporin (Cefuroxime). But he showed significant clinical improvement after being started on PDEi in conjunction with the current antimicrobial therapy. Follow-up after 3 months by clinical examination and penile magnetic resonance imaging in both patients showed normal erectile function with no scarring. Conclusion: PDEi have promising results on disease progression and outcomes. It synergizes the effect of antimicrobial therapy and can potentially reduce the residual corporal fibrosis and erectile dysfunction. However, large studies are required to validate and generalize this treatment approach.Bakhsh A, Daqqaq T, Alhasan A, et al. The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series. Sex Med 2020;8:318–322.http://www.sciencedirect.com/science/article/pii/S2050116120300362CavernositisImpotencePhosphodiesterase Type 5 InhibitorCorpora Cavernosa |
| spellingShingle | Abdulaziz Bakhsh, MD, MBA Tareef Daqqaq, MD Ayman Alhasan, MD Mansour Alnazari, MD Emad Rajih, MD, MPH The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series Sexual Medicine Cavernositis Impotence Phosphodiesterase Type 5 Inhibitor Corpora Cavernosa |
| title | The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series |
| title_full | The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series |
| title_fullStr | The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series |
| title_full_unstemmed | The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series |
| title_short | The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series |
| title_sort | role of phosphodiesterase inhibitors in the management of cavernositis with multifocal abscesses a report of case series |
| topic | Cavernositis Impotence Phosphodiesterase Type 5 Inhibitor Corpora Cavernosa |
| url | http://www.sciencedirect.com/science/article/pii/S2050116120300362 |
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